Arg3.1 Polyclonal Antibody, Invitrogen™

Description

• Immunogen sequence: ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LS Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system
• ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation
• ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons
• Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory
• Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis
• Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses
• Accumulates at weaker synapses, probably to prevent their undesired enhancement
• This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material
• Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory
• Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1
• In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.