PIPA511353
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA511353-Each-of-1 | In Stock | ₹ 47,186.34 |
PIPA511353 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,186.34
GST (18%): ₹ 8,493.541
Total Price: ₹ 55,679.881
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
2.0 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
KLH conjugated synthetic peptide between 393-424 amino acids from the C-terminal region of human Mdm2
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.0 mg/mL
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: KLH conjugated synthetic peptide between 393-424 amino acids from the C-terminal region of human Mdm2
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.0 mg/mL
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
KLH conjugated synthetic peptide between 393-424 amino acids from the C-terminal region of human Mdm2
Quantity:
200 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: PACSIN3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PACSIN3
Gene Alias: 4921507A02Rik; 6330413E15Rik; AW413130; EGK_06300; Endophilin I; PACSIN3; Protein kinase C and casein kinase II substrate protein 3; protein kinase C and casein kinase substrate in neurons 3; protein kinase C and casein kinase substrate in neurons protein 3; SDPIII; SH3 domain-containing protein 6511; syndapin III
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 29763, 311187, 80708
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.7 mg/mL
Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: Q99JB8, Q9UKS6
Gene Symbols: PACSIN3
Immunogen: Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3 protein (1-300AA)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PACSIN3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PACSIN3
Gene Alias:
4921507A02Rik; 6330413E15Rik; AW413130; EGK_06300; Endophilin I; PACSIN3; Protein kinase C and casein kinase II substrate protein 3; protein kinase C and casein kinase substrate in neurons 3; protein kinase C and casein kinase substrate in neurons protein 3; SDPIII; SH3 domain-containing protein 6511; syndapin III
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
29763, 311187, 80708
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.7 mg/mL
Formulation:
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
Q99JB8, Q9UKS6
Gene Symbols:
PACSIN3
Immunogen:
Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3 protein (1-300AA)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: TRAPPC2L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TRAPPC2L
Gene Alias: 1810017G16Rik; AB030200; hematopoietic stem/progenitor cells 176; HSPC126; HSPC176; RGD1304906; Tca17; trafficking protein particle complex 2-like; trafficking protein particle complex subunit 2-like protein; TRAPPC2L
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 51693, 59005
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.5 mg/mL
Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: Q9JME7, Q9UL33
Gene Symbols: TRAPPC2L
Immunogen: Recombinant Human Trafficking protein particle complex subunit 2-like protein (1-139AA)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
TRAPPC2L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TRAPPC2L
Gene Alias:
1810017G16Rik; AB030200; hematopoietic stem/progenitor cells 176; HSPC126; HSPC176; RGD1304906; Tca17; trafficking protein particle complex 2-like; trafficking protein particle complex subunit 2-like protein; TRAPPC2L
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
51693, 59005
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.5 mg/mL
Formulation:
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
Q9JME7, Q9UL33
Gene Symbols:
TRAPPC2L
Immunogen:
Recombinant Human Trafficking protein particle complex subunit 2-like protein (1-139AA)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: INO80
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ino80
Gene Alias: 2310079N15Rik; 4632409L19Rik; Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; Ino80; INO80 complex homolog 1; INO80 complex subunit; INO80 complex subunit A; INO80 homolog; INO80 homolog (S. cerevisiae); INO80A; Inoc1; KIAA1259; putative DNA helicase INO80 complex homolog 1; RGD1310969; yeast INO80-like protein
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 54617
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunocytochemistry, Western Blot
Concentration: 2.81 mg/mL
Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: Q9ULG1
Gene Symbols: Ino80
Immunogen: Recombinant Human Chromatin-remodeling ATPase INO80 protein (1365-1495AA)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
INO80
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ino80
Gene Alias:
2310079N15Rik; 4632409L19Rik; Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; Ino80; INO80 complex homolog 1; INO80 complex subunit; INO80 complex subunit A; INO80 homolog; INO80 homolog (S. cerevisiae); INO80A; Inoc1; KIAA1259; putative DNA helicase INO80 complex homolog 1; RGD1310969; yeast INO80-like protein
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
54617
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunocytochemistry, Western Blot
Concentration:
2.81 mg/mL
Formulation:
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
Q9ULG1
Gene Symbols:
Ino80
Immunogen:
Recombinant Human Chromatin-remodeling ATPase INO80 protein (1365-1495AA)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG