beta-1 Adrenergic Receptor Polyclonal Antibody, Invitrogen™

Description

• Immunogen sequence: CTVWAISALV SFLPILMHWW RAESDEARRC YNDPKCCDFV TNRAYAIASS For short term use, store at 2-8°C up to 1 week
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology: Dog: 87%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100% Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine
• Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family
• Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3)
• ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence
• BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism
• In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function
• Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system
• Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.