PIPA5114115

P4HTM Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5114115-Each-of-1 In Stock ₹ 44,705.10

PIPA5114115 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

P4HTM

Classification

Polyclonal

Conjugate

Unconjugated

Gene

P4HTM

Gene Alias

4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

54681

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Western Blot

Concentration

0.5 mg/mL

Formulation

PBS with 2% sucrose and 0.09% sodium azide

Gene Accession No.

Q9NXG6

Gene Symbols

P4HTM

Immunogen

Synthetic peptide directed towards the middle region of human PH-4

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • Immunogen sequence: RLGNGWWMTP ESIQEMYAAI KADPDGDGVL SLQEFSNMDL RDFHKYMRSH For short term use, store at 2-8°C up to 1 week
  • For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
  • Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha
  • Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen
  • HIF is a transcriptional complex that plays a critical role in oxygen homeostasis
  • Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen
  • In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction
  • Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis
  • Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins
  • It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA5114115

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Antigen:
P4HTM

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
P4HTM

Gene Alias:
4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
54681

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
0.5 mg/mL

Formulation:
PBS with 2% sucrose and 0.09% sodium azide

Gene Accession No.:
Q9NXG6

Gene Symbols:
P4HTM

Immunogen:
Synthetic peptide directed towards the middle region of human PH-4

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114116

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Antigen:
PKM2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PKM

Gene Alias:
AA414905; AL024370; AL024424; ATP:pyruvate 2-o-phosphotransferase; CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; HEL-S-30; isozymes M1/M2; m2pk; muscle pyruvate kinase; OIP3; OIP-3; OPA-interacting protein 3; p58; PK, muscle type; PK2; Pk-2; Pk3; Pk-3; PKLR; PKM; pkm.L; PKM12; PKM2; Pykm; pyruvate kinase; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase M1/2; pyruvate kinase M1/2 L homeolog; pyruvate kinase M1/2 L homeolog; pyruvate kinase, muscle; pyruvate kinase muscle isozyme; Pyruvate kinase PKM; pyruvate kinase, liver and RBC; pyruvate kinase, muscle; TCB; THBP1; thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tu; tumor M2-PK; XELAEV_18018020mg

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
5315

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
0.5 mg/mL

Formulation:
PBS with 2% sucrose and 0.09% sodium azide

Gene Accession No.:
P14618

Gene Symbols:
PKM

Immunogen:
Synthetic peptide directed towards the N terminal region of human PKM2

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114118

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Antigen:
TRIM10

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
TRIM10

Gene Alias:
AI324236; B30-RING finger protein; BB139825; Hematopoietic RING finger 1; Herf1; RFB30; RING finger protein 9; Rnf9; TRIM10; tripartite motif containing 10; tripartite motif protein 10; tripartite motif-containing 10; tripartite motif-containing protein 10; Zn-finger protein

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
10107

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
0.5 mg/mL

Formulation:
PBS with 2% sucrose and 0.09% sodium azide

Gene Accession No.:
Q9UDY6

Gene Symbols:
TRIM10

Immunogen:
Synthetic peptide directed towards the C terminal region of human TRIM10

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114119

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Antigen:
FOXA1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
FOXA1

Gene Alias:
Ci-fkh; fkd7; fkh; fork head domain; forkhead box A1; forkhead box protein A1; forkhead-7; Foxa1; FoxA4a; hepatocyte nuclear factor 3 alpha (winged helix transcription factor); hepatocyte nuclear factor 3, alpha; hepatocyte nuclear factor 3-alpha; HNF3A; HNF-3A; HNF3alpha; HNF-3-alpha; HNF3-alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF3A; Tcf-3a; tFoxA1; Transcription factor 3A; xfkh1; xfkh2

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3169

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot

Concentration:
0.5 mg/mL

Formulation:
PBS with 2% sucrose and 0.09% sodium azide

Gene Accession No.:
P55317

Gene Symbols:
FOXA1

Immunogen:
Synthetic peptide directed towards the N terminal region of human FOXA1

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG