PIPA5114873

Arg3.1 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5114873-Each-of-1 In Stock ₹ 44,705.10

PIPA5114873 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

Arg3.1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Arc

Gene Alias

activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Arc; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; arg3.1; Arg3.1/ARC; C86064; Growth factor ARC; hArc; KIAA0278; mArc; rg3.1; RGD:62037}

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

11838, 23237, 54323

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.

Q63053, Q7LC44, Q9WV31

Gene Symbols

Arc

Immunogen

A synthesized peptide derived from human ARC(Accession Q7LC44), corresponding to amino acid residues K268-E318.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Antibody detects endogenous levels of total Arc
  • Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system
  • ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation
  • ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons
  • Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory
  • Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis
  • Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses
  • Accumulates at weaker synapses, probably to prevent their undesired enhancement
  • This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material
  • Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory
  • Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1
  • In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA5114873

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Antigen:
Arg3.1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Arc

Gene Alias:
activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Arc; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; arg3.1; Arg3.1/ARC; C86064; Growth factor ARC; hArc; KIAA0278; mArc; rg3.1; RGD:62037}

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11838, 23237, 54323

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
Q63053, Q7LC44, Q9WV31

Gene Symbols:
Arc

Immunogen:
A synthesized peptide derived from human ARC(Accession Q7LC44), corresponding to amino acid residues K268-E318.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114874

--


Antigen:
ARF1/ARF3/ARF5/ARF6

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ARF3

Gene Alias:
5430400P17Rik; AA407803; Ac1-253; ADP ribosylation factor 1; ADP ribosylation factor 3; ADP ribosylation factor 4; ADP ribosylation factor 5; ADP ribosylation factor 6; ADP-ribosylation factor 1; ADP-ribosylation factor 2; ADP-ribosylation factor 3; ADP-ribosylation factor 4; ADP-ribosylation factor 4-like protein; ADP-ribosylation factor 5; ADP-ribosylation factor 6; AI788669; AI854770; ARF; Arf1; Arf2; ARF3; ARF4; Arf5; ARF6; AW496366; I79_003112; Liver regeneration-related protein LRRG202; pan ARF; small GTP binding protein

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
140940, 375, 377, 378, 381, 382, 64310, 79117, 79119, 79120, 79121

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
P18085, P61204, P61206, P61751, P62330, P62332, P84077, P84079, P84082, P84083, P84085

Gene Symbols:
ARF1, Arf2, ARF3, Arf4, ARF5, ARF6

Immunogen:
A synthesized peptide derived from human ARF3(Accession P61204), corresponding to amino acid residues H146-K181.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114875

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Antigen:
Argonaute 4

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
AGO4

Gene Alias:
5730550L01Rik; AGO4; AI481660; argonaute 4; argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; argonaute RISC catalytic subunit 4; argonaute RISC component 4; argonaute4; eIF2C 4; eIF-2C 4; Eif2c4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; hAgo4; KIAA1567; LOW QUALITY PROTEIN: protein argonaute-4; mAgo4; Piwi/Argonaute family protein meIF2C4; Protein argonaute-4

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
192670, 298533, 76850

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
Q8CJF8, Q9HCK5

Gene Symbols:
AGO4

Immunogen:
A synthesized peptide derived from human AGO4(Accession Q9HCK5), corresponding to amino acid residues R58-T108.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5114876

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Antigen:
ARHGEF4

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Arhgef4

Gene Alias:
9330140K16Rik; APC-stimulated guanine nucleotide exchange factor; APC-stimulated guanine nucleotide exchange factor 1; Arhgef4; Asef; ASEF1; DKFZp434G2016; ENSMUSG00000070955; GEF4; Kiaa1112; LOC100067370; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 4; Rho guanine nucleotide exchange factor (GEF) 4; Rho guanine nucleotide exchange factor 4; STM6

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
226970, 301334, 50649

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
Q7TNR9, Q9NR80

Gene Symbols:
Arhgef4

Immunogen:
A synthesized peptide derived from human ARHGEF4(Accession Q9NR80), corresponding to amino acid residues R327-E377.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG