PIPA5117233
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117233-Each-of-1 | In Stock | ₹ 47,271.90 |
PIPA5117233 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,271.90
GST (18%): ₹ 8,508.942
Total Price: ₹ 55,780.842
Antigen
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Aurka
Gene Alias
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114592, 261730, 292554, 6790, 6795, 9212
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
2.33 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
O14965, O55099, P59241, Q96GD4, Q9UQB9
Gene Symbols
Aurka, Aurkb, AURKC
Immunogen
A synthetic phosphorylated peptide around T288 of human AURKA/AURKB/AURKCAURKA (NP_0035912)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa Immunogen sequence: RTTLC Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis
- The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly
- Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis
- Required for central/midzone spindle assembly and cleavage furrow formation
- Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515)
- AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP
- Phosphorylation of INCENP leads to increased AURKB activity
- Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3
- A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres
- Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively)
- A positive feedback between GSG2 and AURKB contributes to CPC localization
- AURKB is also required for kinetochore localization of BUB1 and SGOL1
- Phosphorylation of p53/TP53 negatively regulates its transcriptional activity
- Key regulator of active promoters in resting B- and T-lymphocytes.
Compare Similar Items
Show Difference
Antigen: Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Aurka
Gene Alias: Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114592, 261730, 292554, 6790, 6795, 9212
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 2.33 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: O14965, O55099, P59241, Q96GD4, Q9UQB9
Gene Symbols: Aurka, Aurkb, AURKC
Immunogen: A synthetic phosphorylated peptide around T288 of human AURKA/AURKB/AURKCAURKA (NP_0035912)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Aurka
Gene Alias:
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114592, 261730, 292554, 6790, 6795, 9212
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
2.33 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
O14965, O55099, P59241, Q96GD4, Q9UQB9
Gene Symbols:
Aurka, Aurkb, AURKC
Immunogen:
A synthetic phosphorylated peptide around T288 of human AURKA/AURKB/AURKCAURKA (NP_0035912)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-p53 (Ser6)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7157
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.22 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: P04637
Gene Symbols: Tp53
Immunogen: A synthetic phosphorylated peptide around S6 of human p53 (NP_0005373)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-p53 (Ser6)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7157
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.22 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P04637
Gene Symbols:
Tp53
Immunogen:
A synthetic phosphorylated peptide around S6 of human p53 (NP_0005373)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-MYL9 (Thr18, Ser19)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MYL9
Gene Alias: 20 kDa myosin light chain; AI327049; DTNB; G1; Isoform L20-A; LC20; light polypeptide 9; MGC3505; MLC2; MLC-2; MLC20; MLC-2C; MRLC1; myl9; myl9.L; myl9b; myl9l; Mylc2c; myosin light chain 2; myosin light chain 9; myosin light chain 9 L homeolog; myosin light chain, regulatory C; myosin regulatory light chain; myosin regulatory light chain 1; myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2, smooth muscle major isoform; myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; myosin regulatory light polypeptide 9; myosin regulatory light polypeptide 9b; myosin RLC; myosin, light chain 9, regulatory; myosin, light chain 9b, regulatory; myosin, light polypeptide 9, regulatory; Myrl2; RLC-C; smooth muscle major isoform; unnamed protein product; XELAEV_18003093mg; zgc:77916
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10398, 296313, 98932
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.93 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: P24844, Q64122, Q9CQ19
Gene Symbols: MYL9
Immunogen: A synthetic phosphorylated peptide around T18 & S19 of human MYL9 (NP_0060882)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MYL9 (Thr18, Ser19)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MYL9
Gene Alias:
20 kDa myosin light chain; AI327049; DTNB; G1; Isoform L20-A; LC20; light polypeptide 9; MGC3505; MLC2; MLC-2; MLC20; MLC-2C; MRLC1; myl9; myl9.L; myl9b; myl9l; Mylc2c; myosin light chain 2; myosin light chain 9; myosin light chain 9 L homeolog; myosin light chain, regulatory C; myosin regulatory light chain; myosin regulatory light chain 1; myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2, smooth muscle major isoform; myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; myosin regulatory light polypeptide 9; myosin regulatory light polypeptide 9b; myosin RLC; myosin, light chain 9, regulatory; myosin, light chain 9b, regulatory; myosin, light polypeptide 9, regulatory; Myrl2; RLC-C; smooth muscle major isoform; unnamed protein product; XELAEV_18003093mg; zgc:77916
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10398, 296313, 98932
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.93 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P24844, Q64122, Q9CQ19
Gene Symbols:
MYL9
Immunogen:
A synthetic phosphorylated peptide around T18 & S19 of human MYL9 (NP_0060882)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-PKC alpha (Ser657, Tyr658)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PRKCA
Gene Alias: AAG6; aging-associated gene 6; AI875142; EC 2.7.11.13; FHC; FTH; FTHL6; im:7139045; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; Pkca; PKC-A; PKC-alpha; PKC-III; PKRCA; PLIF; PRKACA; Prkca; prkcaa; protein kinase C; protein kinase C alpha; protein kinase C alpha type; protein kinase C alpha type; protein kinase C, alpha, a; protein kinase C, alpha; protein kinase C, alpha, a; protein kinase c-alpha; si:dkey-8l19.1; Unknown (protein for IMAGE:7139045); unnamed protein product
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5578
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.8 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: P17252
Gene Symbols: PRKCA
Immunogen: A synthetic phosphorylated peptide around S657 & Y658 of human PKC alpha (NP_0027282)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-PKC alpha (Ser657, Tyr658)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PRKCA
Gene Alias:
AAG6; aging-associated gene 6; AI875142; EC 2.7.11.13; FHC; FTH; FTHL6; im:7139045; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; Pkca; PKC-A; PKC-alpha; PKC-III; PKRCA; PLIF; PRKACA; Prkca; prkcaa; protein kinase C; protein kinase C alpha; protein kinase C alpha type; protein kinase C alpha type; protein kinase C, alpha, a; protein kinase C, alpha; protein kinase C, alpha, a; protein kinase c-alpha; si:dkey-8l19.1; Unknown (protein for IMAGE:7139045); unnamed protein product
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5578
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.8 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P17252
Gene Symbols:
PRKCA
Immunogen:
A synthetic phosphorylated peptide around S657 & Y658 of human PKC alpha (NP_0027282)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG