PIPA5117306

Phospho-Histone H2A.X (Ser139) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5117306-Each-of-1 In Stock ₹ 45,047.34

PIPA5117306 - Each of 1

₹ 45,047.34

In Stock

Quantity

1

Base Price: ₹ 45,047.34

GST (18%): ₹ 8,108.521

Total Price: ₹ 53,155.861

Antigen

Phospho-Histone H2A.X (Ser139)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

H2AX

Gene Alias

AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

3014, 394048

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.

P16104, Q7ZUY3

Gene Symbols

H2AX

Immunogen

Carrier-protein conjugated synthetic peptide corresponding to residues around zebrafish Histone H2A.XS139ph (phospho Ser139). The exact sequence is proprietary.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Zebrafish

Product Type

Antibody

Isotype

IgG

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Description

  • Centrifuge briefly prior to opening
  • Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
  • In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
  • The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
  • The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
  • Structurally, H2A.x contains 143 amino acid residues
  • Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
  • There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
  • The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
  • Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
  • Histone H2A.x contributes to histone-formation and therefore the structure of DNA
  • Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.

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Show Difference

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Thermo Scientific

PIPA5117306

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Antigen:
Phospho-Histone H2A.X (Ser139)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H2AX

Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3014, 394048

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.:
P16104, Q7ZUY3

Gene Symbols:
H2AX

Immunogen:
Carrier-protein conjugated synthetic peptide corresponding to residues around zebrafish Histone H2A.XS139ph (phospho Ser139). The exact sequence is proprietary.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Zebrafish

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5117307

--


Antigen:
Influenza B Virus

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
Influenza virus; Influenza-B

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 20% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
The immunogen used to generate this antibody corresponds to Influenza B Virus

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Virus

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5117308

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Antigen:
PRRS Virus Nucleocapsid Protein

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
Porcine reproductive and respiratory syndrome virus ORF7; PRRSV ORF7

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
0.27 mg/mL

Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
Full length PRRS virus Nucleocapsid recombinant protein.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Virus

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5117309

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Antigen:
GABARAPL1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
GABARAPL1

Gene Alias:
3110025G09Rik; 9130422N19Rik; AI196471; Apg8l; APG8LIKE; APG8-LIKE; ATG8; ATG8B; Atg8l; Early estrogen-regulated protein; GABA type A receptor associated protein like 1; GABA(A) receptor-associated protein like 1; GABA(A) receptor-associated protein-like 1; GABA(A)-RAP; GABARAPL1; GABARAPL1-a; gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1; gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1; gamma-aminobutyric acid receptor-associated protein-like 1; gamma-aminobutyric acid-receptor-associated protein; Gec1; GEC-1; GECI; Glandular epithelial cell protein 1; MDBK gamma-aminobutyric acid-receptor-associated protein; MNCb-0091

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23710

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.:
Q9H0R8

Gene Symbols:
GABARAPL1

Immunogen:
Full length human GABARAPL1 Recombinant protein.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG