PIPA5118048
HPK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5118048-Each-of-1 | In Stock | ₹ 37,903.08 |
PIPA5118048 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,903.08
GST (18%): ₹ 6,822.554
Total Price: ₹ 44,725.634
Antigen
HPK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP4K1
Gene Alias
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
11184
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.
Q92918
Gene Symbols
MAP4K1
Immunogen
E. coli-derived Human MAP4K1 fragment
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Description
- MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family
- MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway
- MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76
- The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells
- The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation
- We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells
- HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade
- Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo
- HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant
- Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1.
Compare Similar Items
Show Difference
Antigen: HPK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAP4K1
Gene Alias: EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 11184
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: Q92918
Gene Symbols: MAP4K1
Immunogen: E. coli-derived Human MAP4K1 fragment
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
HPK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAP4K1
Gene Alias:
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
11184
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
Q92918
Gene Symbols:
MAP4K1
Immunogen:
E. coli-derived Human MAP4K1 fragment
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: MBD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MBD4
Gene Alias: 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 8930
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: PBS with no preservative
Gene Accession No.: O95243
Gene Symbols: MBD4
Immunogen: A synthetic peptide corresponding to the center region of the Human MBD4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
MBD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MBD4
Gene Alias:
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
8930
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
PBS with no preservative
Gene Accession No.:
O95243
Gene Symbols:
MBD4
Immunogen:
A synthetic peptide corresponding to the center region of the Human MBD4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: MBLAC2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MBLAC2
Gene Alias: MBLAC2; metallo-beta-lactamase domain containing 2; metallo-beta-lactamase domain-containing protein 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 153364
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: Q68D91
Gene Symbols: MBLAC2
Immunogen: E. coli-derived Human MBLAC2 fragment
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
MBLAC2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MBLAC2
Gene Alias:
MBLAC2; metallo-beta-lactamase domain containing 2; metallo-beta-lactamase domain-containing protein 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
153364
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
Q68D91
Gene Symbols:
MBLAC2
Immunogen:
E. coli-derived Human MBLAC2 fragment
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: MCC
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Mcc
Gene Alias: colorectal mutant cancer protein; D18Ertd451e; E330037C19; MCC; MCC1; mutated in colorectal cancers; Protein MCC
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4163
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: P23508
Gene Symbols: Mcc
Immunogen: E. coli-derived Human MCC fragment
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
MCC
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Mcc
Gene Alias:
colorectal mutant cancer protein; D18Ertd451e; E330037C19; MCC; MCC1; mutated in colorectal cancers; Protein MCC
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4163
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
P23508
Gene Symbols:
Mcc
Immunogen:
E. coli-derived Human MCC fragment
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid