PIPA5118200
Presenilin 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5118200-Each-of-1 | In Stock | ₹ 37,903.08 |
PIPA5118200 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,903.08
GST (18%): ₹ 6,822.554
Total Price: ₹ 44,725.634
Antigen
Presenilin 1
Classification
Polyclonal
Formulation
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.
P49768
Gene Symbols
PSEN1
Immunogen
E. coli-derived Human PSEN1 fragment
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
PSEN1
Gene Alias
AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5663
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Description
- Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease
- In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer
- This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease
- Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site)
- It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease
- Multiple isoforms of presenilin1 are known to exist.
Compare Similar Items
Show Difference
Antigen: Presenilin 1
Classification: Polyclonal
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: P49768
Gene Symbols: PSEN1
Immunogen: E. coli-derived Human PSEN1 fragment
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: PSEN1
Gene Alias: AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5663
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Antigen:
Presenilin 1
Classification:
Polyclonal
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
P49768
Gene Symbols:
PSEN1
Immunogen:
E. coli-derived Human PSEN1 fragment
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
PSEN1
Gene Alias:
AD3; Ad3h; Alzheimer Disease 3; FAD; Minilin; presenilin 1; presenilin 1 (Alzheimer disease 3); presenilin1; presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS1; PS-1; PS1-CTF12; PSEN1; Psnl1; S182; S182 protein; Senilin 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5663
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Antigen: PSMB8
Classification: Polyclonal
Formulation: PBS with no preservative
Gene Accession No.: P28062
Gene Symbols: Psmb8
Immunogen: A synthetic peptide corresponding to the C-terminus of the Human PSMB8
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: Psmb8
Gene Alias: ALDD; D6S216; D6S216E; DAAP-57C1.3; JMP; large multifunctional protease 7; Lmp7; Lmp-7; low molecular mass polypeptide 7; low molecular mass protein 7; low molecular weight protein 7; macropain subunit C13; Mc13; MC13 (LMP7); MGC1491; multicatalytic endopeptidase complex subunit C13; NKJO; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; protease component C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta 8; proteasome subunit beta type 8; proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteasome subunit Y2; proteasome-related gene 7; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; PSMB5i; Psmb8; Really interesting new gene 10 protein; Ring10; Y2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5696
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Antigen:
PSMB8
Classification:
Polyclonal
Formulation:
PBS with no preservative
Gene Accession No.:
P28062
Gene Symbols:
Psmb8
Immunogen:
A synthetic peptide corresponding to the C-terminus of the Human PSMB8
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
Psmb8
Gene Alias:
ALDD; D6S216; D6S216E; DAAP-57C1.3; JMP; large multifunctional protease 7; Lmp7; Lmp-7; low molecular mass polypeptide 7; low molecular mass protein 7; low molecular weight protein 7; macropain subunit C13; Mc13; MC13 (LMP7); MGC1491; multicatalytic endopeptidase complex subunit C13; NKJO; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; protease component C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta 8; proteasome subunit beta type 8; proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteasome subunit Y2; proteasome-related gene 7; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; PSMB5i; Psmb8; Really interesting new gene 10 protein; Ring10; Y2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5696
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Antigen: PSMC4
Classification: Polyclonal
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: P43686
Gene Symbols: PSMC4
Immunogen: E. coli-derived Human PSMC4 fragment
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: PSMC4
Gene Alias: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PSMC4; RPT3; S6; S6 ATPase; Tat-binding protein 7; TBP7; TBP-7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5704
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Antigen:
PSMC4
Classification:
Polyclonal
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
P43686
Gene Symbols:
PSMC4
Immunogen:
E. coli-derived Human PSMC4 fragment
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
PSMC4
Gene Alias:
26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PSMC4; RPT3; S6; S6 ATPase; Tat-binding protein 7; TBP7; TBP-7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5704
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Antigen: PSMD2
Classification: Polyclonal
Formulation: PBS with 0.03% ProClin 300; pH 7
Gene Accession No.: Q13200
Gene Symbols: PSMD2
Immunogen: A synthetic peptide corresponding to the N-terminus of the Human PSMD2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: PSMD2
Gene Alias: 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome non-ATPase regulatory subunit 2-like protein; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; 9430095H01Rik; AA407121; F23F1.8; I79_017809; MGC14274; P97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S subunit, non-ATPase 2; protein 55.11; PSMD2; RPN1; S2; TEG-190; testis expressed gene 190; Tex190; TNFR-associated protein 2; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5708
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Antigen:
PSMD2
Classification:
Polyclonal
Formulation:
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.:
Q13200
Gene Symbols:
PSMD2
Immunogen:
A synthetic peptide corresponding to the N-terminus of the Human PSMD2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
PSMD2
Gene Alias:
26S proteasome non-ATPase regulatory subunit 2; 26S proteasome non-ATPase regulatory subunit 2-like protein; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; 9430095H01Rik; AA407121; F23F1.8; I79_017809; MGC14274; P97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S subunit, non-ATPase 2; protein 55.11; PSMD2; RPN1; S2; TEG-190; testis expressed gene 190; Tex190; TNFR-associated protein 2; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5708
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG