SIRP alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5119416-Each-of-1 | In Stock | ₹ 38,416.44 |
PIPA5119416 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,416.44
GST (18%): ₹ 6,914.959
Total Price: ₹ 45,331.399
Antigen
SIRP alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIRPA
Gene Alias
AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140885
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
P78324
Gene Symbols
SIRPA
Immunogen
Recombinant protein Signal Regulatory Protein Alpha. The antigen corresponds to amino acid range 105-324 of the target protein.
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells
- SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways
- The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2
- Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs
- SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes
- Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.
Compare Similar Items
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Antigen: SIRP alpha
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SIRPA
Gene Alias: AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 140885
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.: P78324
Gene Symbols: SIRPA
Immunogen: Recombinant protein Signal Regulatory Protein Alpha. The antigen corresponds to amino acid range 105-324 of the target protein.
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen: SLIT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SLIT1
Gene Alias: KIAA0813; Megf4; mKIAA0813; Multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains 4; multiple epidermal growth factor-like domains protein 4; SLIL1; slit guidance ligand 1; slit homolog 1; slit homolog 1 (Drosophila); slit homolog 1 protein; SLIT1; Slit-1; SLIT3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 65047
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.: O88279
Gene Symbols: SLIT1
Immunogen: Recombinant protein Slit Homolog 1. The antigen corresponds to amino acid range 611-791 of the target protein.
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Rat
Product Type: Antibody
Isotype: IgG
Antigen: SLIT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SLIT1
Gene Alias: KIAA0813; Megf4; mKIAA0813; Multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains 4; multiple epidermal growth factor-like domains protein 4; SLIL1; slit guidance ligand 1; slit homolog 1; slit homolog 1 (Drosophila); slit homolog 1 protein; SLIT1; Slit-1; SLIT3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 65047
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.: O88279
Gene Symbols: SLIT1
Immunogen: Recombinant protein Slit Homolog 1. The antigen corresponds to amino acid range 308-512 of the target protein.
Quantity: 200 μL
Primary or Secondary: Primary
Target Species: Rat
Product Type: Antibody
Isotype: IgG
