GNAS (R201H Mutant) Polyclonal Antibody, Invitrogen™

Description

• Store as concentrated solution
• Centrifuge briefly prior to opening vial
• For short-term storage (1-2 weeks), store at 4°C
• For long-term storage, aliquot and store at -20°C or below
• Avoid multiple freeze-thaw cycles
• This locus has a highly complex imprinted expression pattern
• It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons
• Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression
• This gene has an antisense transcript
• One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region
• In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex
• Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses
• Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined
• [provided by RefSeq, Jun 2015]