p16INK4a Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5119712-Each-of-1 | In Stock | ₹ 43,079.46 |
PIPA5119712 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,079.46
GST (18%): ₹ 7,754.303
Total Price: ₹ 50,833.763
Antigen
p16INK4a
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDKN2A
Gene Alias
Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16 INK4; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; Cdkn2a; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; Cyclin dependent kinase 4 inhibitor A; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; HGNC:1787; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; isoforms 1/2/3; Melanoma p16 inhibits CDK4; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14 P16; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; p16INK4a; p16-INK4a; P19; P19 TP16; p19<ARF>; P19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1029, 12578
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
TBS with 1% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P42771, Q64364
Gene Symbols
CDKN2A
Immunogen
Recombinant protein within human aa DKN2A 1-200
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: Mouse brain tissue lysates, JAR, MCF-7, mouse placenta tissue, mouse colon tissue, mouse brain tissue, 293
- Subcellular Location: Cytoplasm, Nucleus
- This gene generates several transcript variants which differ in their first exons
- At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase
- The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants
- This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53
- In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control
- This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Compare Similar Items
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Antigen: p16INK4a
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CDKN2A
Gene Alias: Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16 INK4; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; Cdkn2a; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; Cyclin dependent kinase 4 inhibitor A; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; HGNC:1787; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; isoforms 1/2/3; Melanoma p16 inhibits CDK4; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14 P16; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; p16INK4a; p16-INK4a; P19; P19 TP16; p19<ARF>; P19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1029, 12578
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: TBS with 1% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: P42771, Q64364
Gene Symbols: CDKN2A
Immunogen: Recombinant protein within human aa DKN2A 1-200
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen: CLIC1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CLIC1
Gene Alias: Chloride channel ABP; chloride intracellular channel 1; chloride intracellular channel protein; chloride intracellular channel protein 1; chloride intracellular channel protein 1 {ECO:0000250; Clcp; CLIC1; clic1 {ECO:0000312; CLIC1 protein; CLIC1; NCC27; DADB-110M10.1; EMBL:CAE83985.1, ECO:0000312; EMBL:CAE83985.1}; FLJ94671; G6; hRNCC; hypothetical protein LOC324481; NCC27; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein; RGD:1303043}; RNCC protein; UniProtKB:O00299, ECO:0000312; wu:fc30e04; zgc:77044
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 114584, 1192, 406864
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: TBS with 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: O00299, Q6MG61, Q9Z1Q5
Gene Symbols: CLIC1
Immunogen: Recombinant protein within Human CLIC1 aa 1-200
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen: SIX2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SIX2
Gene Alias: homeobox protein SIX2; Sine oculis homeobox homolog 2; sine oculis-related homeobox 2; sine oculis-related homeobox 2 homolog; SIX homeobox 2; SIX2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20472
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.: Q62232
Gene Symbols: SIX2
Immunogen: Synthetic peptide within mouse six2 aa 100-160
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG
