Menin Polyclonal Antibody, Invitrogen™

Description

• Positive test controls include: HeLa, HepG2, K-562
• The target is usually found in the following locations: Nucleus
• Immunogen sequence: QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP AASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL SFLKRQRKGL Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells
• One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+)
• Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization
• Maxi K+ dual activation is possible because of its structure
• The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain
• In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry
• The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.