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PIPA5120620

PERK Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA5120620-Each-of-1 In Stock ₹ 43,079.46

PIPA5120620 - Each of 1

₹ 43,079.46

In Stock

Quantity

1

Base Price: ₹ 43,079.46

GST (18%): ₹ 7,754.303

Total Price: ₹ 50,833.763

Antigen

PERK

Classification

Polyclonal

Conjugate

Unconjugated

Gene

EIF2AK3

Gene Alias

2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS

Host Species

Rabbit

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

13666, 29702, 9451

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunocytochemistry, Western Blot

Concentration

0.98 mg/mL

Formulation

PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3

Gene Accession No.

Q9NZJ5, Q9Z1Z1, Q9Z2B5

Gene Symbols

EIF2AK3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 867-1116 of human PERK (NP_004827.4).

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Positive test controls include: Mouse thymus
  • The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type I membrane protein
  • Immunogen sequence: LTKNTTEKLQ PSSPKVYLYI QMQLCRKENL KDWMNGRCTI EERERSVCLH IFLQIAEAVE FLHSKGLMHR DLKPSNIFFT MDDVVKVGDF GLVTAMDQDE EEQTVLTPMP AYARHTGQVG TKLYMSPEQI HGNSYSHKVD IFSLGLILFE LLYPFSTQME RVRTLTDVRN LKFPPLFTQK YPCEYVMVQD MLSPSPMERP EAINIIENAV FEDLDFPGKT VLRQRSRSLS SSGTKHSRQS NNSHSPLPSN EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis
  • In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER
  • Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus
  • WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Compare Similar Items

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Img

Thermo Scientific

PIPA5120620

--

Antigen:
PERK
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EIF2AK3
Gene Alias:
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13666, 29702, 9451
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.98 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
Q9NZJ5, Q9Z1Z1, Q9Z2B5
Gene Symbols:
EIF2AK3
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 867-1116 of human PERK (NP_004827.4).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA5120622

--

Antigen:
Ub-K29
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
UBB
Gene Alias:
__
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
192255, 22187, 7314
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Dot Blot, Western Blot
Concentration:
0.47 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P0CG47, P0CG49, P0CG51
Gene Symbols:
UBB
Immunogen:
A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K29 linkage)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA5120623

--

Antigen:
Ub-K33
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
UBB
Gene Alias:
__
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
192255, 22187, 7314
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Dot Blot, Western Blot
Concentration:
0.31 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P0CG47, P0CG49, P0CG51
Gene Symbols:
UBB
Immunogen:
A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K33 linkage)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA5120624

--

Antigen:
Ub-M1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
UBB
Gene Alias:
__
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
192255, 22187, 7314
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Dot Blot, Western Blot
Concentration:
0.87 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P0CG47, P0CG49, P0CG51
Gene Symbols:
UBB
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human M1-linkage Specific Polyubiquitin (NP_066289.3/NP_061828.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG