PIPA5120750
SARM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5120750-Each-of-1 | In Stock | ₹ 44,811.50 |
PIPA5120750 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
SARM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SARM1
Gene Alias
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23098
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
2.05 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
Q6SZW1
Gene Symbols
SARM1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Positive test controls include: 293T, SH-SY5Y
- Immunogen sequence: ALDKCMQDHD CKDWVHKEIV TALSCGKNIV PIIDGFEWPE PQVLPEDMQA VLTFNGIKWS HEYQEATIEK IIRFLQGRSS RDSSAGSDTS LEGAAPMGPT NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607)
- Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823)
- Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792)
- Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922)
- Can activate neuronal cell death in response to stress (PubMed:20306472)
- Regulates dendritic arborization through the MAPK4-JNK pathway
- Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262)
- [UniProt]
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Antigen: SARM
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SARM1
Gene Alias: A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23098
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 2.05 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: Q6SZW1
Gene Symbols: SARM1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SARM
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SARM1
Gene Alias:
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23098
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
2.05 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
Q6SZW1
Gene Symbols:
SARM1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Cerebral Protein 1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Rrp8
Gene Alias: 1500003O22Rik; 2900001K19Rik; AW538116; Cerebral protein 1; cerebral protein 1 homolog; HUCE1; hucep1; hucep-1; KIAA0409; NML; Nucleomethylin; RGD1308302; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8; Rrp8; RRP-8; RRP8 methyltransferase homolog
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 101867, 23378, 308911
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.104 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: O43159, Q5U4F0, Q9DB85
Gene Symbols: Rrp8
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RRP8 (NP_056139.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cerebral Protein 1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Rrp8
Gene Alias:
1500003O22Rik; 2900001K19Rik; AW538116; Cerebral protein 1; cerebral protein 1 homolog; HUCE1; hucep1; hucep-1; KIAA0409; NML; Nucleomethylin; RGD1308302; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8; Rrp8; RRP-8; RRP8 methyltransferase homolog
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
101867, 23378, 308911
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.104 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
O43159, Q5U4F0, Q9DB85
Gene Symbols:
Rrp8
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RRP8 (NP_056139.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEIS3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MEIS3
Gene Alias: AI573393; Homeobox protein Meis3; Meis homeobox 3; Meis homeobox 3 pseudogene 1; Meis1, myeloid ecotropic viral integration site 1 homolog 3; meis1-related protein 2; Meis3; MEIS3P1; Mrg2; myeloid ecotropic viral integration site-related gene 2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17537, 361514, 56917
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.881 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P97368, Q99687
Gene Symbols: MEIS3
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 325-375 of human MEIS3 (NP_001287988.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MEIS3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MEIS3
Gene Alias:
AI573393; Homeobox protein Meis3; Meis homeobox 3; Meis homeobox 3 pseudogene 1; Meis1, myeloid ecotropic viral integration site 1 homolog 3; meis1-related protein 2; Meis3; MEIS3P1; Mrg2; myeloid ecotropic viral integration site-related gene 2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17537, 361514, 56917
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.881 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P97368, Q99687
Gene Symbols:
MEIS3
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 325-375 of human MEIS3 (NP_001287988.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD3 zeta (CD247)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CD247
Gene Alias: 4930549J05Rik; A430104F18Rik; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; Cd3; CD3 antigen, zeta polypeptide; CD3 zeta; CD3 zeta chain; CD3e antigen; CD3-epsilon; Cd3-eta; CD3H; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; FLJ18683; IMD25; T3E; T3z; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface glycoprotein CD3 zeta chain; TCR zeta chain; TCRE; Tcrk; TCRZ; TCRzeta
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12503, 25300, 919
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.58 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P20963, P24161
Gene Symbols: CD247
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-164 of human CD3H (NP_932170.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CD3 zeta (CD247)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CD247
Gene Alias:
4930549J05Rik; A430104F18Rik; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; Cd3; CD3 antigen, zeta polypeptide; CD3 zeta; CD3 zeta chain; CD3e antigen; CD3-epsilon; Cd3-eta; CD3H; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; FLJ18683; IMD25; T3E; T3z; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface glycoprotein CD3 zeta chain; TCR zeta chain; TCRE; Tcrk; TCRZ; TCRzeta
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12503, 25300, 919
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.58 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P20963, P24161
Gene Symbols:
CD247
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-164 of human CD3H (NP_932170.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG