PIPA5121356
Phospho-PKR (Thr446) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121356-Each-of-1 | In Stock | ₹ 43,079.46 |
PIPA5121356 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,079.46
GST (18%): ₹ 7,754.303
Total Price: ₹ 50,833.763
Antigen
Phospho-PKR (Thr446)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
EIF2AK2
Gene Alias
2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19106, 5610
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
2.62 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P19525, Q03963
Gene Symbols
EIF2AK2
Immunogen
A synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (NP_002750.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Description
- Positive test controls include: HeLa
- The target is usually found in the following locations: Cytoplasm, Nucleus, perinuclear region
- Immunogen sequence: KRTRSK EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses
- EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection
- PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation
- PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway
- Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies
- PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway
- PKR has been implicated in tumor suppression & malignancy
- To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus
- More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
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Antigen: Phospho-PKR (Thr446)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EIF2AK2
Gene Alias: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19106, 5610
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 2.62 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P19525, Q03963
Gene Symbols: EIF2AK2
Immunogen: A synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (NP_002750.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-PKR (Thr446)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EIF2AK2
Gene Alias:
2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19106, 5610
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
2.62 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P19525, Q03963
Gene Symbols:
EIF2AK2
Immunogen:
A synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (NP_002750.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-Beclin 1 (Ser15)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BECN1
Gene Alias: 4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114558, 56208, 8678
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.63 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: O88597, Q14457, Q91XJ1
Gene Symbols: BECN1
Immunogen: A synthetic phosphorylated peptide around S15 of human Beclin 1 (NP_003757.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Beclin 1 (Ser15)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BECN1
Gene Alias:
4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114558, 56208, 8678
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.63 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
O88597, Q14457, Q91XJ1
Gene Symbols:
BECN1
Immunogen:
A synthetic phosphorylated peptide around S15 of human Beclin 1 (NP_003757.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-p53 (Thr81)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 24842, 7157
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.737 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P04637, P10361
Gene Symbols: Tp53
Immunogen: A synthetic phosphorylated peptide around T81 of human TP53 (NP_0005373)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-p53 (Thr81)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
24842, 7157
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.737 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P04637, P10361
Gene Symbols:
Tp53
Immunogen:
A synthetic phosphorylated peptide around T81 of human TP53 (NP_0005373)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-Beclin 1 (Ser90)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BECN1
Gene Alias: 4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 56208, 8678
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.24 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: O88597, Q14457
Gene Symbols: BECN1
Immunogen: A synthetic phosphorylated peptide around S90 of human Beclin 1 (NP_003757.1).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Beclin 1 (Ser90)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BECN1
Gene Alias:
4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
56208, 8678
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.24 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
O88597, Q14457
Gene Symbols:
BECN1
Immunogen:
A synthetic phosphorylated peptide around S90 of human Beclin 1 (NP_003757.1).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG