COL4A4 Polyclonal Antibody, Invitrogen™

Description

• Collagens are highly conserved and are characterized by an uninterrupted Glycine-X-Y triplet repeat
• Col1, the fibrillar collagen found in most connective tissues, is the only component of the collagen found in cartilage
• Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis
• Col2, a fibrillar collagen found in cartilage and the vitreous humor of the eye
• Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia
• Col3 is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen
• Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, aortic and arterial aneurysms
• Col4 is a major consitiuent of the basement membranes along with laminins and enactins
• It is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio
• Col4 antibodies are useful in detecting the loss of parts of basement membrane in carcinomas
• Col5 is found in tissues containing Col1 and appears to regulate the assembly of heterotypic fibers composed of both Col1 and Col5
• Col5 is closely related to type XI collagen; mutations in this gene are associated with Ehlers-Danlos syndrome.