PIPA512919
Phospho-MDM2 (Thr218) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA512919-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA512919 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Phospho-MDM2 (Thr218)
Classification
Polyclonal
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T218 of human MDM2
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Dot Blot
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
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Antigen: Phospho-MDM2 (Thr218)
Classification: Polyclonal
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T218 of human MDM2
Quantity: 400 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Dot Blot
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-MDM2 (Thr218)
Classification:
Polyclonal
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T218 of human MDM2
Quantity:
400 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Dot Blot
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-PIK3CD (Tyr485)
Classification: Polyclonal
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: O00329
Gene Symbols: PIK3CD
Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y485 of human PIK3CD
Quantity: 400 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Dot Blot
Conjugate: Unconjugated
Gene: PIK3CD
Gene Alias: 2410099E07Rik; 2610208K16Rik; APDS; AW545373; catalytic phosphatidylinositol 3-kinase delta; IMD14; p100 delta; p110D; p110delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide 3 kinase P110delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3K; PI3K delta; pi3kcd; PI3Kdelta; PI3K-delta; PI3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5293
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-PIK3CD (Tyr485)
Classification:
Polyclonal
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
O00329
Gene Symbols:
PIK3CD
Immunogen:
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y485 of human PIK3CD
Quantity:
400 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Dot Blot
Conjugate:
Unconjugated
Gene:
PIK3CD
Gene Alias:
2410099E07Rik; 2610208K16Rik; APDS; AW545373; catalytic phosphatidylinositol 3-kinase delta; IMD14; p100 delta; p110D; p110delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide 3 kinase P110delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3K; PI3K delta; pi3kcd; PI3Kdelta; PI3K-delta; PI3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5293
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-EGFR (Tyr1016)
Classification: Polyclonal
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1016 of human EGFR
Quantity: 400 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Dot Blot, Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-EGFR (Tyr1016)
Classification:
Polyclonal
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1016 of human EGFR
Quantity:
400 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Dot Blot, Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Phospho-c-Raf (Ser339)
Classification: Polyclonal
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: P04049
Gene Symbols: Raf1
Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S339 of human RAF1
Quantity: 400 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: Ig
Applications: Dot Blot, Immunocytochemistry
Conjugate: Unconjugated
Gene: Raf1
Gene Alias: 6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5894
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-c-Raf (Ser339)
Classification:
Polyclonal
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
P04049
Gene Symbols:
Raf1
Immunogen:
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S339 of human RAF1
Quantity:
400 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
Ig
Applications:
Dot Blot, Immunocytochemistry
Conjugate:
Unconjugated
Gene:
Raf1
Gene Alias:
6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5894
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid