PIPA513124

CRY1 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA513124-Each-of-1 In Stock ₹ 46,844.10

PIPA513124 - Each of 1

₹ 46,844.10

In Stock

Quantity

1

Base Price: ₹ 46,844.10

GST (18%): ₹ 8,431.938

Total Price: ₹ 55,276.038

Antigen

CRY1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

CRY1

Gene Alias

AU020726; AU021000; Cry1; cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1; PHLL1

Host Species

Rabbit

Purification Method

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status

RUO

Gene ID (Entrez)

1407

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Western Blot

Concentration

1.8 mg/mL

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

Q16526

Gene Symbols

CRY1

Immunogen

KLH conjugated synthetic peptide between 556-586 amino acids from the C-terminal region of human Cry1

Quantity

400 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • This antibody is predicted to react with non-human primate based on sequence homology
  • Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock
  • The central &quotegears&quote driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop
  • Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases
  • In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function
  • Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM
  • They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors
  • Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively
  • It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases
  • A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

Compare Similar Items

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Thermo Scientific

PIPA513124

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Antigen:
CRY1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CRY1

Gene Alias:
AU020726; AU021000; Cry1; cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1; PHLL1

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
1407

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.8 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q16526

Gene Symbols:
CRY1

Immunogen:
KLH conjugated synthetic peptide between 556-586 amino acids from the C-terminal region of human Cry1

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA513125

--


Antigen:
CRY2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CRY2

Gene Alias:
AV006279; CRY2; cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2; D130054K12Rik; growth-inhibiting protein 37; HCRY2; Kiaa0658; PHLL2

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
12953, 1408

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
2 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q49AN0, Q9R194

Gene Symbols:
CRY2

Immunogen:
KLH conjugated synthetic peptide between 564-593 amino acids from the C-terminal region of human Cry2

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA513127

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Antigen:
S1P1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
S1PR1

Gene Alias:
AI849002; CD antigen CD363; CD363; CD363 antigen; CHEDG1; D1S3362; ECGF1; EDG1; EDG-1; EDG1 (Edg1); Edg1; rhodopsin family G protein-coupled receptor; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; etID43307.22; Lpb1; Lysophospholipid receptor B1; S1p; S1P receptor 1; S1P receptor Edg-1; s1p1; S1PR1; sphingosine 1-phosphate receptor; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor EDG1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1; wu:fb98f05

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
13609, 1901

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1.3 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
O08530, P21453

Gene Symbols:
S1PR1

Immunogen:
KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human EDG1

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA513129

--


Antigen:
EDG3

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
S1PR3

Gene Alias:
AI132464; cardiac sphingosine-1-phosphate specific receptor; EDG3; EDG-3; Edg3l; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lpb3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; S1P receptor S1P3; S1p3; S1PR3; sphingosine; Sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
13610, 1903

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1.8 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q99500, Q9Z0U9

Gene Symbols:
S1PR3

Immunogen:
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EDG3

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG