PIPA517785
PKR Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517785-Each-of-1 | In Stock | ₹ 38,844.24 |
PIPA517785 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,844.24
GST (18%): ₹ 6,991.963
Total Price: ₹ 45,836.203
Antigen
PKR
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
P19525
Gene Symbols
EIF2AK2
Immunogen
Synthetic peptide corresponding to residues surrounding Thr451 of human PKR
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
EIF2AK2
Gene Alias
2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2A
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5610
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with other related proteins
- EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses
- EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection
- PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation
- PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway
- Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies
- PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway
- PKR has been implicated in tumor suppression & malignancy
- To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus
- More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
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Antigen: PKR
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P19525
Gene Symbols: EIF2AK2
Immunogen: Synthetic peptide corresponding to residues surrounding Thr451 of human PKR
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: EIF2AK2
Gene Alias: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2A
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5610
Content And Storage: -20°C
Form: Liquid
Antigen:
PKR
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P19525
Gene Symbols:
EIF2AK2
Immunogen:
Synthetic peptide corresponding to residues surrounding Thr451 of human PKR
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
EIF2AK2
Gene Alias:
2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2A
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5610
Content And Storage:
-20°C
Form:
Liquid
Antigen: PAK1/2/3
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: O75914, O88643, P35465, Q13153, Q13177, Q61036, Q62829, Q64303, Q8CIN4
Gene Symbols: Pak1, PAK2, PAK3
Immunogen: Synthetic peptide corresponding to residues at the carboxy-terminus of human PAK1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Conjugate: Unconjugated
Gene: Pak1
Gene Alias: 5330420P17Rik; A130002K10Rik; activated protein kinase alpha; ADRB2; adriamycin resistance-associated; AI836325; Alpha-PAK; ARA; AW045634; Beta-PAK; bPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; C-t-PAK2; D16Ertd269e; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; mKIAA4182; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p27; p34; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; Pak1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAKalpha; Pakb; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast; Stk4
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18479, 18481, 224105, 29431, 29432, 29433, 5058, 5062, 5063
Content And Storage: -20°C
Form: Liquid
Antigen:
PAK1/2/3
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
O75914, O88643, P35465, Q13153, Q13177, Q61036, Q62829, Q64303, Q8CIN4
Gene Symbols:
Pak1, PAK2, PAK3
Immunogen:
Synthetic peptide corresponding to residues at the carboxy-terminus of human PAK1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
Pak1
Gene Alias:
5330420P17Rik; A130002K10Rik; activated protein kinase alpha; ADRB2; adriamycin resistance-associated; AI836325; Alpha-PAK; ARA; AW045634; Beta-PAK; bPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; C-t-PAK2; D16Ertd269e; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; mKIAA4182; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p27; p34; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; Pak1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAKalpha; Pakb; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast; Stk4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18479, 18481, 224105, 29431, 29432, 29433, 5058, 5062, 5063
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-MAPKAPK2 (Thr334)
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P49137, P49138
Gene Symbols: MAPKAPK2
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pThr334 of human MAPKAPK-2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Gene: MAPKAPK2
Gene Alias: AA960234; MAP kinase-activated protein kinase 2; MAPK activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; Mapkapk2; MAPKAP-K2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2; MK2; MK-2; Rps6kc1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17164, 289014, 9261
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-MAPKAPK2 (Thr334)
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P49137, P49138
Gene Symbols:
MAPKAPK2
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pThr334 of human MAPKAPK-2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Gene:
MAPKAPK2
Gene Alias:
AA960234; MAP kinase-activated protein kinase 2; MAPK activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; Mapkapk2; MAPKAP-K2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2; MK2; MK-2; Rps6kc1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17164, 289014, 9261
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-PDPK1 (Ser241)
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: O15530, O55173, Q9Z2A0
Gene Symbols: Pdpk1
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pSer241 of human PDK1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Gene: Pdpk1
Gene Alias: 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18607, 5170, 81745
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-PDPK1 (Ser241)
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
O15530, O55173, Q9Z2A0
Gene Symbols:
Pdpk1
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pSer241 of human PDK1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Gene:
Pdpk1
Gene Alias:
3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18607, 5170, 81745
Content And Storage:
-20°C
Form:
Liquid