PIPA519952
BACE1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA519952-Each-of-1 | In Stock | ₹ 50,394.84 |
PIPA519952 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,394.84
GST (18%): ₹ 9,071.071
Total Price: ₹ 59,465.911
Antigen
BACE1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BACE1
Gene Alias
APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species
Rabbit
Purification Method
Ion-exchange chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23621, 23821
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P56817, P56818
Gene Symbols
BACE1
Immunogen
A peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is human brain tissue lysate
- PA5-19952 can be used with blocking peptide PEP-0077
- The PA5-19952 immunogen is located within the last 50 amino acids of BACE
- Predicted molecular ∽ 55kD
- In Western blot applications, this antibody has been observed to detect a band at: 65kD (Post-modification: 4 N-linked glycosylation)
- Predicted species reactivity based on immunogen sequence: Guinea pig: (94%), Rat: (94%), Bovine: (94%)
- BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD)
- In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1
- This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff
- APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99)
- The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease
- The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)
- bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Compare Similar Items
Show Difference
Antigen: BACE1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BACE1
Gene Alias: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species: Rabbit
Purification Method: Ion-exchange chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23621, 23821
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: P56817, P56818
Gene Symbols: BACE1
Immunogen: A peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
BACE1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BACE1
Gene Alias:
APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
Host Species:
Rabbit
Purification Method:
Ion-exchange chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23621, 23821
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
P56817, P56818
Gene Symbols:
BACE1
Immunogen:
A peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: F1A alpha
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FEM1B
Gene Alias: DKFZp451E0710; F1aa; F1A-alpha; fem-1 homolog B; fem-1 homolog b (C. elegans); Fem1b; FEM1-beta; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; feminization 1 homolog b (C. elegans); FIAA; Kiaa0396; mKIAA0396; mt-Fem; Protein fem-1 homolog B
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10116, 14155, 315745
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: P0C6P7, Q9UK73, Q9Z2G0
Gene Symbols: FEM1B
Immunogen: A peptide corresponding to amino acids 609 to 622 of human F1A alpha
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
F1A alpha
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FEM1B
Gene Alias:
DKFZp451E0710; F1aa; F1A-alpha; fem-1 homolog B; fem-1 homolog b (C. elegans); Fem1b; FEM1-beta; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; feminization 1 homolog b (C. elegans); FIAA; Kiaa0396; mKIAA0396; mt-Fem; Protein fem-1 homolog B
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10116, 14155, 315745
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
P0C6P7, Q9UK73, Q9Z2G0
Gene Symbols:
FEM1B
Immunogen:
A peptide corresponding to amino acids 609 to 622 of human F1A alpha
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RIP3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RIPK3
Gene Alias: 2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11035, 246240, 56532
Content And Storage: 4° C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q9QZL0, Q9Y572, Q9Z2P5
Gene Symbols: RIPK3
Immunogen: A 14 amino acid peptide near the carboxy terminus of murine RIP3
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
RIP3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RIPK3
Gene Alias:
2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11035, 246240, 56532
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q9QZL0, Q9Y572, Q9Z2P5
Gene Symbols:
RIPK3
Immunogen:
A 14 amino acid peptide near the carboxy terminus of murine RIP3
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: PYCARD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PYCARD
Gene Alias: 9130417A21Rik; Apoptosis-associated speck-like protein containing a CARD; Asc; CARD5; caspase recruitment domain-containing protein 5; hASC; mASC; MGC10332; Pycard; PYD and CARD domain containing; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; TMS; TMS1; TMS-1; TNS1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29108
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q9ULZ3
Gene Symbols: PYCARD
Immunogen: A 14 amino acid peptide near the carboxy terminus of human ASC
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
PYCARD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PYCARD
Gene Alias:
9130417A21Rik; Apoptosis-associated speck-like protein containing a CARD; Asc; CARD5; caspase recruitment domain-containing protein 5; hASC; mASC; MGC10332; Pycard; PYD and CARD domain containing; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; TMS; TMS1; TMS-1; TNS1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29108
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q9ULZ3
Gene Symbols:
PYCARD
Immunogen:
A 14 amino acid peptide near the carboxy terminus of human ASC
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG