PIPA520059
SARM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520059-Each-of-1 | In Stock | ₹ 47,699.70 |
PIPA520059 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,699.70
GST (18%): ₹ 8,585.946
Total Price: ₹ 56,285.646
Antigen
SARM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SARM1
Gene Alias
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23098, 237868
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q6PDS3, Q6SZW1
Gene Symbols
SARM1
Immunogen
A peptide corresponding to amino acids near the C-terminus of human SARM.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Description
- A suggested positive control is Daudi cell lysate
- PA5-20059 can be used with blocking peptide PEP-0178
- NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607)
- Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823)
- Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792)
- Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922)
- Can activate neuronal cell death in response to stress (PubMed:20306472)
- Regulates dendritic arborization through the MAPK4-JNK pathway
- Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262)
- [UniProt]
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Antigen: SARM
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SARM1
Gene Alias: A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23098, 237868
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q6PDS3, Q6SZW1
Gene Symbols: SARM1
Immunogen: A peptide corresponding to amino acids near the C-terminus of human SARM.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
SARM
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SARM1
Gene Alias:
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23098, 237868
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q6PDS3, Q6SZW1
Gene Symbols:
SARM1
Immunogen:
A peptide corresponding to amino acids near the C-terminus of human SARM.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: ARMER
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ARL6IP1
Gene Alias: ADP ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1-like protein; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; AIP1; aip-1; AIP-6; AL022945; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Arl6ip; arl6ip protein; Arl6ip1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; Protein TBX2; SPG61; zgc:56593; zgc:77873
Host Species: Rabbit
Purification Method: Ion-exchange chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23204, 54208
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q15041, Q9JKW0
Gene Symbols: ARL6IP1
Immunogen: A peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
ARMER
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ARL6IP1
Gene Alias:
ADP ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1-like protein; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; AIP1; aip-1; AIP-6; AL022945; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Arl6ip; arl6ip protein; Arl6ip1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; Protein TBX2; SPG61; zgc:56593; zgc:77873
Host Species:
Rabbit
Purification Method:
Ion-exchange chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23204, 54208
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q15041, Q9JKW0
Gene Symbols:
ARL6IP1
Immunogen:
A peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: DAD1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DAD1
Gene Alias: AI323713; Dad1; DAD-1; Defender against cell death 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase 2 homolog; oligosaccharyltransferase subunit 2 (non-catalytic); OST2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13135, 1603
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: P61803, P61804
Gene Symbols: DAD1
Immunogen: A peptide corresponding to 14 amino acids near the C-terminus of human DAD1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
DAD1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DAD1
Gene Alias:
AI323713; Dad1; DAD-1; Defender against cell death 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase 2 homolog; oligosaccharyltransferase subunit 2 (non-catalytic); OST2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13135, 1603
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
P61803, P61804
Gene Symbols:
DAD1
Immunogen:
A peptide corresponding to 14 amino acids near the C-terminus of human DAD1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: NAIP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NAIP
Gene Alias: AV364616; baculoviral IAP repeat-containing 1a; baculoviral IAP repeat-containing protein 1; Baculoviral IAP repeat-containing protein 1a; BIRC1; Birc1a; D13Lsd1; FLJ18088; FLJ42520; FLJ58811; Naip; Naip1; Naip-rs1; Neuronal apoptosis inhibitory protein; neuronal apoptosis inhibitory protein 1; NLR family apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein 1; NLRB1; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein; psiNAIP
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4671
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q13075
Gene Symbols: NAIP
Immunogen: A synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
NAIP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NAIP
Gene Alias:
AV364616; baculoviral IAP repeat-containing 1a; baculoviral IAP repeat-containing protein 1; Baculoviral IAP repeat-containing protein 1a; BIRC1; Birc1a; D13Lsd1; FLJ18088; FLJ42520; FLJ58811; Naip; Naip1; Naip-rs1; Neuronal apoptosis inhibitory protein; neuronal apoptosis inhibitory protein 1; NLR family apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein 1; NLRB1; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein; psiNAIP
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4671
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q13075
Gene Symbols:
NAIP
Immunogen:
A synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG