PIPA520170

AES Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA520170-Each-of-1 In Stock ₹ 44,705.10

PIPA520170 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

AES

Classification

Polyclonal

Conjugate

Unconjugated

Gene

AES

Gene Alias

Aes; AES-1; AES-2; AL024115; Amino enhancer of split; amino-terminal enhancer of split; Esp1; gp130-associated protein GAM; Grg; Grg5; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; related to Drosophila groucho; R-esp1; TLE family member 5; TLE family member 5, transcriptional modulator; TLE family member 5; amino-terminal enhancer of split; TLE5

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

14797, 166

Content And Storage

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Form

Liquid

Applications

Immunocytochemistry, Western Blot

Concentration

1 mg/mL

Formulation

PBS with 0.02% sodium azide

Gene Accession No.

P63002, Q08117

Gene Symbols

AES, TLE5

Immunogen

A 16 amino acid peptide from near the amino-terminus of human AES.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG

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Description

  • A suggested positive control is 293 cell lysate
  • PA5-20170 can be used with blocking peptide PEP-0287
  • Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading
  • Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment
  • Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination
  • AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis
  • It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family
  • Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

Compare Similar Items

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Img

Thermo Scientific

PIPA520170

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Antigen:
AES

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
AES

Gene Alias:
Aes; AES-1; AES-2; AL024115; Amino enhancer of split; amino-terminal enhancer of split; Esp1; gp130-associated protein GAM; Grg; Grg5; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; related to Drosophila groucho; R-esp1; TLE family member 5; TLE family member 5, transcriptional modulator; TLE family member 5; amino-terminal enhancer of split; TLE5

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
14797, 166

Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
P63002, Q08117

Gene Symbols:
AES, TLE5

Immunogen:
A 16 amino acid peptide from near the amino-terminus of human AES.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA520171

--


Antigen:
Beclin 1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
BECN1

Gene Alias:
4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
56208, 8678

Content And Storage:
4° C

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
O88597, Q14457

Gene Symbols:
BECN1

Immunogen:
A 16 amino acid peptide from near the carboxy terminus of human Beclin-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA520172

--


Antigen:
Beclin 1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
BECN1

Gene Alias:
4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
114558, 56208, 8678

Content And Storage:
4° C

Form:
Liquid

Applications:
Immunohistochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
O88597, Q14457, Q91XJ1

Gene Symbols:
BECN1

Immunogen:
A 17 amino acid peptide from near the amino terminus of human Beclin-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA520174

--


Antigen:
ATG7

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ATG7

Gene Alias:
1810013K23Rik; Agp7; APG7L; APG7-LIKE; ATG12-activating enzyme E1 ATG7; Atg7; ATG7 autophagy related 7 homolog; Atg7l; autophagy related 7; autophagy related 7 homolog; autophagy-related 7; autophagy-related protein 7; DKFZp434N0735; Gm21553; GSA7; hAGP7; ubiquitin-activating enzyme E1-like protein; Ubiquitin-like modifier-activating enzyme ATG7

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
10533, 74244

Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 0.02% sodium azide

Gene Accession No.:
O95352, Q9D906

Gene Symbols:
ATG7

Immunogen:
A 17 amino acid peptide from near the amino terminus of human APG7.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG