PIPA521092
PION Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA521092-Each-of-1 | In Stock | ₹ 47,528.58 |
PIPA521092 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,528.58
GST (18%): ₹ 8,555.144
Total Price: ₹ 56,083.724
Antigen
PION
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GSAP
Gene Alias
A530088I07Rik; gamma-secretase activating protein; gamma-secretase-activating protein; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; pigeon homolog; Pion; Protein pigeon homolog; tcag7.1314
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
212167, 311984, 54103
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
A4D1B5, Q3TCV3
Gene Symbols
GSAP
Immunogen
A 19 amino acid peptide near the carboxy terminus of human PION.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is EL4 cell lysate
- PA5-21092 can be used with blocking peptide PEP-1206
- Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease
- The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99)
- The C99 fragment serves as substrate for -gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients’ brains
- PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both -gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease.
Compare Similar Items
Show Difference
Antigen: PION
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GSAP
Gene Alias: A530088I07Rik; gamma-secretase activating protein; gamma-secretase-activating protein; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; pigeon homolog; Pion; Protein pigeon homolog; tcag7.1314
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 212167, 311984, 54103
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: A4D1B5, Q3TCV3
Gene Symbols: GSAP
Immunogen: A 19 amino acid peptide near the carboxy terminus of human PION.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PION
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GSAP
Gene Alias:
A530088I07Rik; gamma-secretase activating protein; gamma-secretase-activating protein; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; pigeon homolog; Pion; Protein pigeon homolog; tcag7.1314
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
212167, 311984, 54103
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
A4D1B5, Q3TCV3
Gene Symbols:
GSAP
Immunogen:
A 19 amino acid peptide near the carboxy terminus of human PION.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: AXIN2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AXIN2
Gene Alias: Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12006, 29134, 8313
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: O70240, O88566, Q9Y2T1
Gene Symbols: AXIN2
Immunogen: A 20 amino acid peptide near the carboxy terminus of human AXIN2.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
AXIN2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AXIN2
Gene Alias:
Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12006, 29134, 8313
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
O70240, O88566, Q9Y2T1
Gene Symbols:
AXIN2
Immunogen:
A 20 amino acid peptide near the carboxy terminus of human AXIN2.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: FBXL16
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FBXL16
Gene Alias: BC042620; C16orf22; c380A1.1; c380A1.1 (novel protein); FBL16; F-box and leucine rich repeat protein 16; F-box and leucine-rich repeat protein 16; F-box/LRR-repeat protein 16; Fbxl16; Scirr1; spinal cord injury and regeneration related 1; spinal cord injury and regeneration-related protein 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 146330, 214931, 494223
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: A2RT62, Q5MJ12, Q8N461
Gene Symbols: FBXL16
Immunogen: An 18 amino acid peptide near the carboxy terminus of human FBXL16
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
FBXL16
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FBXL16
Gene Alias:
BC042620; C16orf22; c380A1.1; c380A1.1 (novel protein); FBL16; F-box and leucine rich repeat protein 16; F-box and leucine-rich repeat protein 16; F-box/LRR-repeat protein 16; Fbxl16; Scirr1; spinal cord injury and regeneration related 1; spinal cord injury and regeneration-related protein 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
146330, 214931, 494223
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
A2RT62, Q5MJ12, Q8N461
Gene Symbols:
FBXL16
Immunogen:
An 18 amino acid peptide near the carboxy terminus of human FBXL16
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: ZBTB9
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ZBTB9
Gene Alias: 3930402F13Rik; DASS-97D12.7; Zbtb9; zinc finger and BTB domain containing 9; zinc finger and BTB domain-containing protein 9; ZNF919
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 221504, 474156
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q8CDC7, Q96C00
Gene Symbols: ZBTB9
Immunogen: A 15 amino acid peptide near the carboxy terminus of human ZBTB9.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
ZBTB9
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ZBTB9
Gene Alias:
3930402F13Rik; DASS-97D12.7; Zbtb9; zinc finger and BTB domain containing 9; zinc finger and BTB domain-containing protein 9; ZNF919
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
221504, 474156
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q8CDC7, Q96C00
Gene Symbols:
ZBTB9
Immunogen:
A 15 amino acid peptide near the carboxy terminus of human ZBTB9.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG