PIPA528093
HPK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528093-Each-of-1 | In Stock | ₹ 47,699.70 |
PIPA528093 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,699.70
GST (18%): ₹ 8,585.946
Total Price: ₹ 56,285.646
Antigen
HPK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP4K1
Gene Alias
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11184
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q92918
Gene Symbols
MAP4K1
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human MAP4K1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HeLa
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family
- MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway
- MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76
- The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells
- The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation
- We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells
- HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade
- Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo
- HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant
- Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1.
Compare Similar Items
Show Difference
Antigen: HPK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAP4K1
Gene Alias: EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11184
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q92918
Gene Symbols: MAP4K1
Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human MAP4K1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
HPK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAP4K1
Gene Alias:
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11184
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q92918
Gene Symbols:
MAP4K1
Immunogen:
Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human MAP4K1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: DUSP10
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DUSP10
Gene Alias: 2610306G15Rik; AI158871; dual specificity phosphatase 10; dual specificity phosphatase MKP-5; dual specificity protein phosphatase 10; Dusp10; MAP kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5; Mkp5; MKP-5; serine/threonine specific protein phosphatase
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11221
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q9Y6W6
Gene Symbols: DUSP10
Immunogen: Synthetic peptide corresponding to a region within amino acids 419 and 482 of Human DUSP10
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
DUSP10
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DUSP10
Gene Alias:
2610306G15Rik; AI158871; dual specificity phosphatase 10; dual specificity phosphatase MKP-5; dual specificity protein phosphatase 10; Dusp10; MAP kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5; Mkp5; MKP-5; serine/threonine specific protein phosphatase
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11221
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q9Y6W6
Gene Symbols:
DUSP10
Immunogen:
Synthetic peptide corresponding to a region within amino acids 419 and 482 of Human DUSP10
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SPHK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SPHK1
Gene Alias: 1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8877
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.17 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: Q9NYA1
Gene Symbols: SPHK1
Immunogen: Synthetic peptide corresponding to a region within amino acids 321 and 384 of Human SPHK1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SPHK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SPHK1
Gene Alias:
1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8877
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.17 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
Q9NYA1
Gene Symbols:
SPHK1
Immunogen:
Synthetic peptide corresponding to a region within amino acids 321 and 384 of Human SPHK1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: p41-ARCb
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ARPC1B
Gene Alias: 41kDa; AA408064; AA408534; AA571392; actin related protein 2/3 complex subunit 1B; actin related protein 2/3 complex subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; Actin-related protein complex 1b; AF007010; ARC41; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; Arpc1b; AW208418; L72; OTTHUMP00000206020; p40-ARC; p41-ARC; SOP2Hs
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10095, 11867
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: O15143, Q9WV32
Gene Symbols: ARPC1B
Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human p41-ARCb
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
p41-ARCb
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ARPC1B
Gene Alias:
41kDa; AA408064; AA408534; AA571392; actin related protein 2/3 complex subunit 1B; actin related protein 2/3 complex subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B; actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; Actin-related protein complex 1b; AF007010; ARC41; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; Arpc1b; AW208418; L72; OTTHUMP00000206020; p40-ARC; p41-ARC; SOP2Hs
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10095, 11867
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
O15143, Q9WV32
Gene Symbols:
ARPC1B
Immunogen:
Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human p41-ARCb
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG