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PIPA530752

P4HTM Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA530752-Each-of-1 In Stock ₹ 45,560.70

PIPA530752 - Each of 1

₹ 45,560.70

In Stock

Quantity

1

Base Price: ₹ 45,560.70

GST (18%): ₹ 8,200.926

Total Price: ₹ 53,761.626

Antigen

P4HTM

Classification

Polyclonal

Conjugate

Unconjugated

Gene

P4HTM

Gene Alias

4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

54681

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.

Q9NXG6

Gene Symbols

P4HTM

Immunogen

Recombinant fragment corresponding to a region within amino acids 99 and 382 of Human HIF Prolyl Hydroxylase 4

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • Recommended positive controls: A549, H1299, HCT116
  • Predicted reactivity: Mouse (94%), Bovine (92%)
  • Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha
  • Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen
  • HIF is a transcriptional complex that plays a critical role in oxygen homeostasis
  • Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen
  • In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction
  • Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis
  • Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins
  • It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Compare Similar Items

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Img

Thermo Scientific

PIPA530752

--

Antigen:
P4HTM
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
P4HTM
Gene Alias:
4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
54681
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q9NXG6
Gene Symbols:
P4HTM
Immunogen:
Recombinant fragment corresponding to a region within amino acids 99 and 382 of Human HIF Prolyl Hydroxylase 4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA530754

--

Antigen:
FBLIM1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FBLIM1
Gene Alias:
2410043F08Rik; CAL; CSX-associated LIM; FBLIM1; FBLP1; FBLP-1; filamin binding LIM protein 1; filamin-binding LIM protein 1; filamin-binding LIM protein-1; Gt10; MIG2-interacting protein; migfilin; migfilin(s); mitogen-inducible 2 interacting protein; mitogen-inducible 2-interacting protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
54751
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.8 mg/mL
Formulation:
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q8WUP2
Gene Symbols:
FBLIM1
Immunogen:
Recombinant fragment corresponding to a region within amino acids 171 and 373 of Human FBLIM1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA530755

--

Antigen:
KLHDC4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
KLHDC4
Gene Alias:
AA408426; AV352552; BC012312; G430025P05Rik; kelch domain containing 4; kelch domain-containing protein 4; KLHDC4; RGD1561676; similar to Kelch domain containing 4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
54758
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q8TBB5
Gene Symbols:
KLHDC4
Immunogen:
Recombinant fragment corresponding to a region within amino acids 51 and 301 of Human KLHDC4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA530756

--

Antigen:
KLHDC4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
KLHDC4
Gene Alias:
AA408426; AV352552; BC012312; G430025P05Rik; kelch domain containing 4; kelch domain-containing protein 4; KLHDC4; RGD1561676; similar to Kelch domain containing 4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
54758
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q8TBB5
Gene Symbols:
KLHDC4
Immunogen:
Recombinant protein fragment corresponding to a region within amino acids 219 and 474 of Human KLHDC4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG