PIPA532249
HMGB1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA532249-Each-of-1 | In Stock | ₹ 50,565.96 |
PIPA532249 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,565.96
GST (18%): ₹ 9,101.873
Total Price: ₹ 59,667.833
Antigen
HMGB1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Hmgb1
Gene Alias
Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15289, 25459, 3146
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
0.17 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P09429, P63158, P63159
Gene Symbols
Hmgb1
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 215 of Human HMGB1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, HeLa, HepG2, mouse brain, rat brain
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- HMGB1 (High-mobility group box-1) protein was originally described as a nuclear non-histone DNA binding chromosomal protein
- However, recent studies indicate that damaged, necrotic cells liberate HMGB1 into the extracellular milieu where it functions as a proinflammatory cytokine
- Mouse HMGB1 is expressed as a 215 amino acid single chain polypeptide containing three domains: two tandem-linked positively charged DNA-binding domains (HMG box A, aa 9-79; and box B, aa 89-162), and a negatively charged 30 aa C-terminal acidic tail region
- Residues 28 - 44 and 180 - 185 contain a nuclear localization signal (NLS)
- The cytokine activity of HMGB1 is contained in the B box, while the A box is associated with the helix-loop-helix domain of transcription factors
- HMGB1 acts both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, as well as a mediator of T cell-dendritic cell interaction
- HMGB1 is secreted and acts to transduce cellular signals through its high affinity receptor, RAGE and possibly, TLR2 and TLR4
- HMGB1 is highly conserved and ubiquitous in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses
- HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE)
- Moreover, HMGB1 is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
Compare Similar Items
Show Difference
Antigen: HMGB1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Hmgb1
Gene Alias: Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15289, 25459, 3146
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 0.17 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: P09429, P63158, P63159
Gene Symbols: Hmgb1
Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 215 of Human HMGB1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
HMGB1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Hmgb1
Gene Alias:
Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15289, 25459, 3146
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
0.17 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
P09429, P63158, P63159
Gene Symbols:
Hmgb1
Immunogen:
Synthetic peptide corresponding to a region within amino acids 1 and 215 of Human HMGB1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Galectin 4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Lgals4
Gene Alias: Antigen NY-CO-27; GAL4; gal-4; galectin 4; galectin-4; L-36; L-36 lactose-binding protein; L36LBI; L36LBP; lactose-binding lectin 4; Lectin galactose binding soluble 4 (Galectin-4); lectin, galactose binding, soluble 4; Lectin, galactose binding, soluble 4 (Galectin-4); lectin, galactoside binding soluble 4; lectin, galactoside-binding, soluble, 4; lectin, galactoside-binding, soluble, 4 (galectin 4); Lgals4
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16855, 3960
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: P56470, Q8K419
Gene Symbols: Lgals4
Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 140 of Human Galectin4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Galectin 4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Lgals4
Gene Alias:
Antigen NY-CO-27; GAL4; gal-4; galectin 4; galectin-4; L-36; L-36 lactose-binding protein; L36LBI; L36LBP; lactose-binding lectin 4; Lectin galactose binding soluble 4 (Galectin-4); lectin, galactose binding, soluble 4; Lectin, galactose binding, soluble 4 (Galectin-4); lectin, galactoside binding soluble 4; lectin, galactoside-binding, soluble, 4; lectin, galactoside-binding, soluble, 4 (galectin 4); Lgals4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16855, 3960
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
P56470, Q8K419
Gene Symbols:
Lgals4
Immunogen:
Recombinant fragment corresponding to a region within amino acids 1 and 140 of Human Galectin4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Influenza A M1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Gene Alias: Influenza M1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 0.37 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: __
Gene Symbols: __
Immunogen: Recombinant protein fragment of influenza A virus M1 (A/Puerto Rico/8/1934(H1N1))
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Virus
Product Type: Antibody
Isotype: IgG
Antigen:
Influenza A M1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
Influenza M1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
0.37 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Recombinant protein fragment of influenza A virus M1 (A/Puerto Rico/8/1934(H1N1))
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Virus
Product Type:
Antibody
Isotype:
IgG
Antigen: BrdU
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Gene Alias: 5-Bromo-2-deoxyuridine; Bromodeoxyuridine
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: __
Gene Symbols: __
Immunogen: BrdU conjugated to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Chemical
Product Type: Antibody
Isotype: IgG
Antigen:
BrdU
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
5-Bromo-2-deoxyuridine; Bromodeoxyuridine
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
BrdU conjugated to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Chemical
Product Type:
Antibody
Isotype:
IgG