Bombesin Receptor 3 Polyclonal Antibody, Invitrogen™

Description

• Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey (95%); Bat, Panda, Rabbit (80%)
• For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer
• After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen
• BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus
• ESTs have been isolated from normal brain and kidney cancer libraries
• G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist
• All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms
• An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors
• Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs
• This &quoteturn-off&quote activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates
• Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.