CD36 Polyclonal Antibody, HRP, Invitrogen™

Description

• Western blot shows a band at approx
• 75-80 kDa
• The difference in theoretical MW and actual MW as seen in Western blot is most likely due to the heavy glycosylation and palmitoylation of this protein.Suggested positive control: antigen standard for CD36 (transient overexpression lysate)
• CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes
• It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells
• CD36 is also implicated in the pathogenesis of malaria
• The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface
• It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes
• Mutations in this gene cause platelet glycoprotein deficiency
• Multiple alternatively spliced transcript variants have been found for this gene
• Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.