PIPA534694
ICAD Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA534694-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA534694 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
ICAD
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114214, 13347, 1676
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
O00273, O54786
Gene Symbols
DFFA
Immunogen
Recombinant fragment corresponding to a region within amino acids 2 and 287 of ICAD (Uniprot ID#O00273)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, Jurkat, Raji
- Predicted reactivity: Mouse (81%), Rat (83%), Rhesus Monkey (94%), Bovine (80%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
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Antigen: ICAD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114214, 13347, 1676
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: O00273, O54786
Gene Symbols: DFFA
Immunogen: Recombinant fragment corresponding to a region within amino acids 2 and 287 of ICAD (Uniprot ID#O00273)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ICAD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114214, 13347, 1676
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
O00273, O54786
Gene Symbols:
DFFA
Immunogen:
Recombinant fragment corresponding to a region within amino acids 2 and 287 of ICAD (Uniprot ID#O00273)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD180
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Cd180
Gene Alias: CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4064
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q99467
Gene Symbols: Cd180
Immunogen: Recombinant fragment corresponding to a region within amino acids 195 and 543 of RP105 (Uniprot ID#Q99467)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
CD180
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Cd180
Gene Alias:
CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4064
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q99467
Gene Symbols:
Cd180
Immunogen:
Recombinant fragment corresponding to a region within amino acids 195 and 543 of RP105 (Uniprot ID#Q99467)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: eIF4E2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EIF4E2
Gene Alias: 2700069E09Rik; 4EHP; 4E-LP; AI036339; AV129531; D0H0S6743E; EGK_04904; eIF4E type 2; eIF-4E type 2; Eif4e2; eIF4E-2; EIF4EL3; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; eukaryotic translation initiation factor 4E family member 2; eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E member 2; eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; IF4e; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 2; mRNA cap-binding protein type 3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26987, 9470
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal, 0.025% ProClin 300; pH 7
Gene Accession No.: O60573, Q8BMB3
Gene Symbols: EIF4E2
Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 242 of EIF4E2 (Uniprot ID#O60573)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
eIF4E2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EIF4E2
Gene Alias:
2700069E09Rik; 4EHP; 4E-LP; AI036339; AV129531; D0H0S6743E; EGK_04904; eIF4E type 2; eIF-4E type 2; Eif4e2; eIF4E-2; EIF4EL3; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; eukaryotic translation initiation factor 4E family member 2; eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E member 2; eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; IF4e; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 2; mRNA cap-binding protein type 3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26987, 9470
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal, 0.025% ProClin 300; pH 7
Gene Accession No.:
O60573, Q8BMB3
Gene Symbols:
EIF4E2
Immunogen:
Recombinant fragment corresponding to a region within amino acids 1 and 242 of EIF4E2 (Uniprot ID#O60573)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Aurora A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AURKA
Gene Alias: Aik; Airk; AIRK1; Ark1; ARK-1; AU019385; AURA; AURAK; AURKA; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; Aurora-A; aurora-related kinase 1; AW539821; Ayk1; Breast tumor-amplified kinase; BTAK; EC 2.7.11.1; hARK1; IAK; IAK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; PPP1R47; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; sereine threonine kinase; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; serine/threonine-protein kinase 6; aurora kinase A; serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1; STK15; STK6; STK7; Unknown (protein for MGC:134472)
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6790
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.87 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: O14965
Gene Symbols: AURKA
Immunogen: Synthetic peptide corresponding to a region within amino acids 343 and 403 of Aurora A (Uniprot ID#O14965)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Aurora A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AURKA
Gene Alias:
Aik; Airk; AIRK1; Ark1; ARK-1; AU019385; AURA; AURAK; AURKA; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; Aurora-A; aurora-related kinase 1; AW539821; Ayk1; Breast tumor-amplified kinase; BTAK; EC 2.7.11.1; hARK1; IAK; IAK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; PPP1R47; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; sereine threonine kinase; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; serine/threonine-protein kinase 6; aurora kinase A; serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1; STK15; STK6; STK7; Unknown (protein for MGC:134472)
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6790
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.87 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
O14965
Gene Symbols:
AURKA
Immunogen:
Synthetic peptide corresponding to a region within amino acids 343 and 403 of Aurora A (Uniprot ID#O14965)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG