PIPA551639
SAV1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA551639-Each-of-1 | In Stock | ₹ 49,410.90 |
PIPA551639 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,410.90
GST (18%): ₹ 8,893.962
Total Price: ₹ 58,304.862
Antigen
SAV1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SAV1
Gene Alias
1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
60485
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9H4B6
Gene Symbols
SAV1
Immunogen
Recombinant protein corresponding to Human SAV1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: IGRVAATSLG NLTNHGSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG WERVESSEFG TYYVDHTNKK AQYRHPCAPS VPRYDQPPPV TYQPQQTERN QSLLVPANPY HTAEIPDWLQ VYARAPVKYD HILKWELFQL A Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%
- Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues
- It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250
- In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
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Antigen: SAV1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SAV1
Gene Alias: 1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 60485
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9H4B6
Gene Symbols: SAV1
Immunogen: Recombinant protein corresponding to Human SAV1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SAV1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SAV1
Gene Alias:
1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
60485
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9H4B6
Gene Symbols:
SAV1
Immunogen:
Recombinant protein corresponding to Human SAV1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Complement Factor B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CFB
Gene Alias: AHUS4; AI195813; AI255840; alternative-complement pathway C3/C5 convertase; ARMD14; B; BF; B-factor, properdin; BFD; C2; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFB; CFBD; complement component 2 (within H-2S); complement factor B; Complement factor B Ba fragment; Complement factor B Bb fragment; Da1-24; DADB-122G4.5; Factor B; Fb; FBI12; GBG; glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein; H2-Bf; histocompatibility 2, complement component factor B; PBF2; properdin; properdin factor B
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 629
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry
Concentration: 0.08 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: P00751
Gene Symbols: CFB
Immunogen: Recombinant protein corresponding to Human Complement Factor B
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Complement Factor B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CFB
Gene Alias:
AHUS4; AI195813; AI255840; alternative-complement pathway C3/C5 convertase; ARMD14; B; BF; B-factor, properdin; BFD; C2; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFB; CFBD; complement component 2 (within H-2S); complement factor B; Complement factor B Ba fragment; Complement factor B Bb fragment; Da1-24; DADB-122G4.5; Factor B; Fb; FBI12; GBG; glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein; H2-Bf; histocompatibility 2, complement component factor B; PBF2; properdin; properdin factor B
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
629
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry
Concentration:
0.08 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
P00751
Gene Symbols:
CFB
Immunogen:
Recombinant protein corresponding to Human Complement Factor B
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: ITIH4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ITIH4
Gene Alias: 35 kDa inter-alpha-trypsin inhibitor heavy chain H4; 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; DKFZp686G21125; Gp120; H4P; IHRP; Inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heavy chain-related protein; inter-alpha-trypsin inhibitor heavy chain 4; inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor, heavy chain-like, 1; ITI heavy chain H4; Itih4; Itih-4; ITI-HC4; ITIHL1; PK120; PK-120; Plasma kallikrein sensitive glycoprotein 120; plasma kallikrein-sensitive glycoprotein 120; PRO1851
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3700
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q14624
Gene Symbols: ITIH4
Immunogen: Recombinant protein corresponding to Human ITIH4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ITIH4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ITIH4
Gene Alias:
35 kDa inter-alpha-trypsin inhibitor heavy chain H4; 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; DKFZp686G21125; Gp120; H4P; IHRP; Inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heavy chain-related protein; inter-alpha-trypsin inhibitor heavy chain 4; inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor, heavy chain-like, 1; ITI heavy chain H4; Itih4; Itih-4; ITI-HC4; ITIHL1; PK120; PK-120; Plasma kallikrein sensitive glycoprotein 120; plasma kallikrein-sensitive glycoprotein 120; PRO1851
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3700
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q14624
Gene Symbols:
ITIH4
Immunogen:
Recombinant protein corresponding to Human ITIH4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: EGFL6
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EGFL6
Gene Alias: EGF like domain multiple 6; EGF repeat-containing protein 6; EGFL6; EGF-like protein 6; EGF-like-domain, multiple 6; Epidermal growth factor-like protein 6; Maeg; MAM and EGF domain containing; MAM and EGF domains-containing gene protein; PP648; Protein W80; UNQ281/PRO320; W80
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25975
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8IUX8
Gene Symbols: EGFL6
Immunogen: Recombinant protein corresponding to Human EGFL6
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
EGFL6
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EGFL6
Gene Alias:
EGF like domain multiple 6; EGF repeat-containing protein 6; EGFL6; EGF-like protein 6; EGF-like-domain, multiple 6; Epidermal growth factor-like protein 6; Maeg; MAM and EGF domain containing; MAM and EGF domains-containing gene protein; PP648; Protein W80; UNQ281/PRO320; W80
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25975
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8IUX8
Gene Symbols:
EGFL6
Immunogen:
Recombinant protein corresponding to Human EGFL6
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG