PIPA551670
MBD4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA551670-Each-of-1 | In Stock | ₹ 47,015.22 |
PIPA551670 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,015.22
GST (18%): ₹ 8,462.74
Total Price: ₹ 55,477.96
Antigen
MBD4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MBD4
Gene Alias
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8930
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
O95243
Gene Symbols
MBD4
Immunogen
Recombinant protein corresponding to Human MBD4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: LQNQSNNSNW NLRTRSKCKK DVFMPPSSSS ELQESRGLSN FTSTHLLLKE DEGVDDVNFR KVRKPKGKVT ILKGIPIKKT KKGCRKSCSG FVQSDSKRES VCNKADAESE PVAQKSQLDR TVCISDAGAC GETLSVTSEE N Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 45%
- DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression
- The methylation pattern involves the enzymatic processes of methylation and demethylation
- The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD)
- The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol
- MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA
- MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal
- Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro
- MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity
- MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases
- In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Compare Similar Items
Show Difference
Antigen: MBD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MBD4
Gene Alias: 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8930
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: O95243
Gene Symbols: MBD4
Immunogen: Recombinant protein corresponding to Human MBD4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MBD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MBD4
Gene Alias:
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8930
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
O95243
Gene Symbols:
MBD4
Immunogen:
Recombinant protein corresponding to Human MBD4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: POF1B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: POF1B
Gene Alias: 2310066B14Rik; POF; POF1B; POF1B actin binding protein; POF1B, actin binding protein; POF2B; premature ovarian failure 1B; premature ovarian failure protein 1B; premature ovarian failure, 1B; protein POF1B; RGD1560798
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 79983
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8WVV4
Gene Symbols: POF1B
Immunogen: Recombinant protein corresponding to Human POF1B
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
POF1B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
POF1B
Gene Alias:
2310066B14Rik; POF; POF1B; POF1B actin binding protein; POF1B, actin binding protein; POF2B; premature ovarian failure 1B; premature ovarian failure protein 1B; premature ovarian failure, 1B; protein POF1B; RGD1560798
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
79983
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8WVV4
Gene Symbols:
POF1B
Immunogen:
Recombinant protein corresponding to Human POF1B
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TAPP1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PLEKHA1
Gene Alias: AA960558; C920009D07Rik; PH domain-containing family A member 1; pleckstrin homology domain containing A1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; pleckstrin homology domain-containing protein family A member 1; PLEKHA1; RGD1564153; tandem PH domain containing protein-1; tandem PH domain-containing protein 1; TAPP1; TAPP-1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 59338
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9HB21
Gene Symbols: PLEKHA1
Immunogen: Recombinant protein corresponding to Human TAPP1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TAPP1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PLEKHA1
Gene Alias:
AA960558; C920009D07Rik; PH domain-containing family A member 1; pleckstrin homology domain containing A1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; pleckstrin homology domain-containing protein family A member 1; PLEKHA1; RGD1564153; tandem PH domain containing protein-1; tandem PH domain-containing protein 1; TAPP1; TAPP-1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
59338
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9HB21
Gene Symbols:
PLEKHA1
Immunogen:
Recombinant protein corresponding to Human TAPP1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: PSMC4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PSMC4
Gene Alias: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PSMC4; RPT3; S6; S6 ATPase; Tat-binding protein 7; TBP7; TBP-7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 117262, 23996, 5704
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: P43686, P54775, Q63570
Gene Symbols: PSMC4
Immunogen: Recombinant protein corresponding to Human PSMC4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PSMC4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PSMC4
Gene Alias:
26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PSMC4; RPT3; S6; S6 ATPase; Tat-binding protein 7; TBP7; TBP-7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
117262, 23996, 5704
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
P43686, P54775, Q63570
Gene Symbols:
PSMC4
Immunogen:
Recombinant protein corresponding to Human PSMC4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG