PIPA554087
HMHA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA554087-Each-of-1 | In Stock | ₹ 50,309.28 |
PIPA554087 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,309.28
GST (18%): ₹ 9,055.67
Total Price: ₹ 59,364.95
Antigen
HMHA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ARHGAP45
Gene Alias
6330406L22Rik; ARHGAP45; AW539505; Ha-1; histocompatibility (minor) HA-1; HLA-HA1; Hmha1; KIAA0223; mHag HA-1; Minor histocompatibility antigen HA-1; minor histocompatibility protein HA-1; minor histocompatibility protein HA-1; rho GTPase-activating protein 45; RGD1308662; Rho GTPase activating protein 45; rho GTPase-activating protein 45
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23526
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q92619
Gene Symbols
ARHGAP45
Immunogen
Recombinant protein corresponding to Human HMHA1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: QRAEVVVQVP YLEAGEAVVY PLQEAAADGC RESRVVSNDS DSDLEEASEL LSSSEASALG HLSFLEQQQS EASLEVASGS HSGSEEQLEA TAREDGDGDE DGPAQQLSGF NTNQSNNV Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 56%
- Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading
- However, also contains N-terminally a BAR-domain which is able to play an autoinhibitory effect on this RhoGAP activity
- Precursor of the histocompatibility antigen HA-1
- More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells
- The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing
- The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor
- GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants
- Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT
- HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles
- This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT
- It induces cell recognition and lysis by CTL.
Compare Similar Items
Show Difference
Antigen: HMHA1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ARHGAP45
Gene Alias: 6330406L22Rik; ARHGAP45; AW539505; Ha-1; histocompatibility (minor) HA-1; HLA-HA1; Hmha1; KIAA0223; mHag HA-1; Minor histocompatibility antigen HA-1; minor histocompatibility protein HA-1; minor histocompatibility protein HA-1; rho GTPase-activating protein 45; RGD1308662; Rho GTPase activating protein 45; rho GTPase-activating protein 45
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23526
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q92619
Gene Symbols: ARHGAP45
Immunogen: Recombinant protein corresponding to Human HMHA1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
HMHA1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ARHGAP45
Gene Alias:
6330406L22Rik; ARHGAP45; AW539505; Ha-1; histocompatibility (minor) HA-1; HLA-HA1; Hmha1; KIAA0223; mHag HA-1; Minor histocompatibility antigen HA-1; minor histocompatibility protein HA-1; minor histocompatibility protein HA-1; rho GTPase-activating protein 45; RGD1308662; Rho GTPase activating protein 45; rho GTPase-activating protein 45
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23526
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q92619
Gene Symbols:
ARHGAP45
Immunogen:
Recombinant protein corresponding to Human HMHA1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: ARHGAP23
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ARHGAP23
Gene Alias: ARHGAP23; KIAA1501; Rho GTPase activating protein 23; rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57636
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9P227
Gene Symbols: ARHGAP23
Immunogen: Recombinant protein corresponding to Human ARHGAP23
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ARHGAP23
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ARHGAP23
Gene Alias:
ARHGAP23; KIAA1501; Rho GTPase activating protein 23; rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57636
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9P227
Gene Symbols:
ARHGAP23
Immunogen:
Recombinant protein corresponding to Human ARHGAP23
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: RBM15
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RBM15
Gene Alias: C230088J01Rik; Kiaa4257; mKIAA1438; one twenty two protein; one twenty-two; one-twenty two protein 1; OTT; OTT1; putative RNA-binding protein 15; RBM15; RNA binding motif protein 15; RNA-binding motif protein 15; RNA-binding protein 15; SPEN
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 64783
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.08 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q96T37
Gene Symbols: RBM15
Immunogen: Recombinant protein corresponding to Human RBM15
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
RBM15
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RBM15
Gene Alias:
C230088J01Rik; Kiaa4257; mKIAA1438; one twenty two protein; one twenty-two; one-twenty two protein 1; OTT; OTT1; putative RNA-binding protein 15; RBM15; RNA binding motif protein 15; RNA-binding motif protein 15; RNA-binding protein 15; SPEN
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
64783
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.08 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q96T37
Gene Symbols:
RBM15
Immunogen:
Recombinant protein corresponding to Human RBM15
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: FTSJ2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MRM2
Gene Alias: 16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; 2310037B18Rik; cell division protein FtsJ; epididymis luminal protein 97; FJH1; FtsJ homolog 2; FtsJ homolog 2 (E. coli); FtsJ RNA methyltransferase homolog 2; FTSJ2; HEL97; mitochondrial rRNA methyltransferase 2; Mrm2; MRM2 RNA methyltransferase homolog; protein ftsJ homolog 2; putative ribosomal RNA methyltransferase 2; RRMJ2; rRNA (uridine-2'-O-)-methyltransferase; rRNA methyltransferase 2, mitochondrial
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29960
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.4 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9UI43
Gene Symbols: MRM2
Immunogen: Recombinant protein corresponding to Human FTSJ2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
FTSJ2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MRM2
Gene Alias:
16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; 2310037B18Rik; cell division protein FtsJ; epididymis luminal protein 97; FJH1; FtsJ homolog 2; FtsJ homolog 2 (E. coli); FtsJ RNA methyltransferase homolog 2; FTSJ2; HEL97; mitochondrial rRNA methyltransferase 2; Mrm2; MRM2 RNA methyltransferase homolog; protein ftsJ homolog 2; putative ribosomal RNA methyltransferase 2; RRMJ2; rRNA (uridine-2'-O-)-methyltransferase; rRNA methyltransferase 2, mitochondrial
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29960
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.4 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9UI43
Gene Symbols:
MRM2
Immunogen:
Recombinant protein corresponding to Human FTSJ2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG