SETX Polyclonal Antibody, Invitrogen™

Description

• Immunogen sequence: CCWCTPGGAS TIDFLKRYAS NTPSGEFQTA DEDLCYCLEC VAEYHKARDE LPFLHEVLWE LETLRLINHF EKSMKAEIGD DDELYIVDNN GEMPLFDITG QDFEN Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%
• Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity
• Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224)
• Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850)
• Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805)
• Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation
• Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789)
• In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744)
• Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI)
• May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256)
• Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways
• Inhibits retinoic acid-induced apoptosis (PubMed:21576111).