CRYGS Polyclonal Antibody, Invitrogen™

Description

• Immunogen sequence: GTWAVYERPN FAGYMYILPQ GEYPEYQRWM GLNDRLSSCR AVHLPSGGQY KIQIFEKGDF SGQMYETTED CPSIMEQFHM REIHSCKVLE GVWIFYELP Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%
• Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous
• The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens
• Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins
• Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily
• Alpha and beta families are further divided into acidic and basic groups
• Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions
• Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions
• They are differentially regulated after early development
• This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins
• This gene encodes the most significant gamma-crystallin in adult eye lens tissue
• Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.