PIPA557541
VPRBP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA557541-Each-of-1 | In Stock | ₹ 47,015.22 |
PIPA557541 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,015.22
GST (18%): ₹ 8,462.74
Total Price: ₹ 55,477.96
Antigen
VPRBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9730
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.05 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9Y4B6
Gene Symbols
DCAF1
Immunogen
Recombinant protein corresponding to Human VPRBP
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: FTCCAFSARE RFLMLGTCTG QLKLYNVFSG QEEASYNCHN SAITHLEPSR DGSLLLTSAT WSQPLSALWG MKSVFDMKHS FTEDHYVEFS KHSQDRVIG Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
Compare Similar Items
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Antigen: VPRBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9730
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.05 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9Y4B6
Gene Symbols: DCAF1
Immunogen: Recombinant protein corresponding to Human VPRBP
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
VPRBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9730
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.05 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
Recombinant protein corresponding to Human VPRBP
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: FAM110C
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FAM110C
Gene Alias: FAM110C; family with sequence similarity 110 member C; family with sequence similarity 110, member C; protein FAM110C
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 642273
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q1W6H9
Gene Symbols: FAM110C
Immunogen: Recombinant protein corresponding to Human FAM110C
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
FAM110C
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FAM110C
Gene Alias:
FAM110C; family with sequence similarity 110 member C; family with sequence similarity 110, member C; protein FAM110C
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
642273
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q1W6H9
Gene Symbols:
FAM110C
Immunogen:
Recombinant protein corresponding to Human FAM110C
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: FAM110C
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FAM110C
Gene Alias: FAM110C; family with sequence similarity 110 member C; family with sequence similarity 110, member C; protein FAM110C
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 642273
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q1W6H9
Gene Symbols: FAM110C
Immunogen: Recombinant protein corresponding to Human FAM110C
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
FAM110C
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FAM110C
Gene Alias:
FAM110C; family with sequence similarity 110 member C; family with sequence similarity 110, member C; protein FAM110C
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
642273
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q1W6H9
Gene Symbols:
FAM110C
Immunogen:
Recombinant protein corresponding to Human FAM110C
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TAS2R42
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TAS2R42
Gene Alias: candidate taste receptor hT2R55; hT2R55; T2R24; T2R42; T2R55; TAS2R42; TAS2R55; taste 2 receptor member 42; taste receptor type 2 member 42; taste receptor type 2 member 55; taste receptor, type 2, member 42
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 353164
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q7RTR8
Gene Symbols: TAS2R42
Immunogen: Recombinant protein corresponding to Human TAS2R42
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TAS2R42
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TAS2R42
Gene Alias:
candidate taste receptor hT2R55; hT2R55; T2R24; T2R42; T2R55; TAS2R42; TAS2R55; taste 2 receptor member 42; taste receptor type 2 member 42; taste receptor type 2 member 55; taste receptor, type 2, member 42
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
353164
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q7RTR8
Gene Symbols:
TAS2R42
Immunogen:
Recombinant protein corresponding to Human TAS2R42
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG