PIPA560876
HMCES Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA560876-Each-of-1 | In Stock | ₹ 49,881.48 |
PIPA560876 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,881.48
GST (18%): ₹ 8,978.666
Total Price: ₹ 58,860.146
Antigen
HMCES
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HMCES
Gene Alias
5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56941
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q96FZ2
Gene Symbols
HMCES
Immunogen
Recombinant protein corresponding to Human HMCES
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: WRLLTMAGIF DCWEPPEGGD VLYSYTIITV DSCKGLSDIH HRMPAILDGE EAVSKWLDFG EVSTQEALKL IHPTENITFH AVSSVVNNS Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%
- Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913)
- Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913)
- The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877)
- Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877)
- Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351)
- Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway
- Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine
- [UniProt]
Compare Similar Items
Show Difference
Antigen: HMCES
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HMCES
Gene Alias: 5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 56941
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q96FZ2
Gene Symbols: HMCES
Immunogen: Recombinant protein corresponding to Human HMCES
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
HMCES
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HMCES
Gene Alias:
5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
56941
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q96FZ2
Gene Symbols:
HMCES
Immunogen:
Recombinant protein corresponding to Human HMCES
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TRIM26
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TRIM26
Gene Alias: Acid finger protein; AFP; AI462198; RING finger protein 95; RNF95; TRIM26; tripartite motif containing 26; tripartite motif protein 26; tripartite motif protein TRIM26; tripartite motif-containing 26; tripartite motif-containing protein 26; widely expressed acid zinc finger protein; Zfp173; Zfp1736; zinc finger protein 173; Znf173
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7726
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry
Concentration: 0.8 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q12899
Gene Symbols: TRIM26
Immunogen: Recombinant protein corresponding to Human TRIM26
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TRIM26
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TRIM26
Gene Alias:
Acid finger protein; AFP; AI462198; RING finger protein 95; RNF95; TRIM26; tripartite motif containing 26; tripartite motif protein 26; tripartite motif protein TRIM26; tripartite motif-containing 26; tripartite motif-containing protein 26; widely expressed acid zinc finger protein; Zfp173; Zfp1736; zinc finger protein 173; Znf173
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7726
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry
Concentration:
0.8 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q12899
Gene Symbols:
TRIM26
Immunogen:
Recombinant protein corresponding to Human TRIM26
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: THAP4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: THAP4
Gene Alias: 2010320B01Rik; CGI-36; PP238; THAP domain containing 4; THAP domain-containing protein 4; Thap4
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51078
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8WY91
Gene Symbols: THAP4
Immunogen: Recombinant protein corresponding to Human THAP4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
THAP4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
THAP4
Gene Alias:
2010320B01Rik; CGI-36; PP238; THAP domain containing 4; THAP domain-containing protein 4; Thap4
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51078
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8WY91
Gene Symbols:
THAP4
Immunogen:
Recombinant protein corresponding to Human THAP4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: RNASE2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RNASE2
Gene Alias: EDN; eosinophil-derived neurotoxin; Non-secretory ribonuclease; RAF3; Ribonuclease 2; ribonuclease A F3; ribonuclease A family member 2; ribonuclease US; ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin); RNase 2; RNase UpI-2; RNASE2; RNS2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6036
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.08 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: P10153
Gene Symbols: RNASE2
Immunogen: Recombinant protein corresponding to Human RNASE2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
RNASE2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RNASE2
Gene Alias:
EDN; eosinophil-derived neurotoxin; Non-secretory ribonuclease; RAF3; Ribonuclease 2; ribonuclease A F3; ribonuclease A family member 2; ribonuclease US; ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin); RNase 2; RNase UpI-2; RNASE2; RNS2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6036
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.08 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
P10153
Gene Symbols:
RNASE2
Immunogen:
Recombinant protein corresponding to Human RNASE2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG