Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody, Invitrogen™

Description

• Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody detects endogenous levels of Leptin Receptor only when phosphorylated at Tyr1141
• The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance
• Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway
• Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains
• Several isoforms of the OB-R which differ in length and signaling capabilities have been reported
• RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure
• Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity
• Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.