PIPA570309
HMCES Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA570309-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA570309 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
HMCES
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HMCES
Gene Alias
5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
232210
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
Q8R1M0
Gene Symbols
HMCES
Immunogen
synthetic peptide directed towards the middle region of human HMCES
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This target displays homology in the following species: Cow: 93%; Dog: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 79%; Rabbit: 100%; Rat: 93% Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913)
- Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913)
- The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877)
- Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877)
- Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351)
- Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway
- Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine
- [UniProt]
Compare Similar Items
Show Difference
Antigen: HMCES
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HMCES
Gene Alias: 5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 232210
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.: Q8R1M0
Gene Symbols: HMCES
Immunogen: synthetic peptide directed towards the middle region of human HMCES
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
HMCES
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HMCES
Gene Alias:
5-hydroxymethylcytosine (hmC) binding, ES cell specific; 5-hydroxymethylcytosine (hmC) binding, ES cell-specific; 5-hydroxymethylcytosine binding, ES cell specific; 8430410A17Rik; Abasic site processing protein HMCES; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; C20H3orf37; C22H3orf37; C3orf37; C85376; DC12; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; HMCES; Peptidase HMCES; Putative endonuclease HMCES; putative peptidase SRAPD1; SRAP domain-containing protein 1; Srap1; Srapd1; UPF0361 protein C3orf37; UPF0361 protein C3orf37 homolog
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
232210
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.:
Q8R1M0
Gene Symbols:
HMCES
Immunogen:
synthetic peptide directed towards the middle region of human HMCES
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: RNPEP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Rnpep
Gene Alias: aminopeptidase B; APB; AP-B; Arginine aminopeptidase; arginyl aminopeptidase; arginyl aminopeptidase (aminopeptidase B); cytosol aminopeptidase IV; Rnpep; zgc:100971
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 215615
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.: Q8VCT3
Gene Symbols: Rnpep
Immunogen: synthetic peptide directed towards the C-terminal region of mouse RNPEP
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
RNPEP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Rnpep
Gene Alias:
aminopeptidase B; APB; AP-B; Arginine aminopeptidase; arginyl aminopeptidase; arginyl aminopeptidase (aminopeptidase B); cytosol aminopeptidase IV; Rnpep; zgc:100971
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
215615
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.:
Q8VCT3
Gene Symbols:
Rnpep
Immunogen:
synthetic peptide directed towards the C-terminal region of mouse RNPEP
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: ANKMY2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ankmy2
Gene Alias: AI035571; ANKMY2; ankyrin repeat and MYND domain containing 2; ankyrin repeat and MYND domain-containing protein 2; EGK_13887; Gna14; guanine nucleotide binding protein, alpha 14; LOW QUALITY PROTEIN: ankyrin repeat and MYND domain-containing protein 2; ZMYND20
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57037
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.: Q8IV38
Gene Symbols: Ankmy2
Immunogen: synthetic peptide directed towards the N terminal region of human ANKMY2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ANKMY2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ankmy2
Gene Alias:
AI035571; ANKMY2; ankyrin repeat and MYND domain containing 2; ankyrin repeat and MYND domain-containing protein 2; EGK_13887; Gna14; guanine nucleotide binding protein, alpha 14; LOW QUALITY PROTEIN: ankyrin repeat and MYND domain-containing protein 2; ZMYND20
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57037
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.:
Q8IV38
Gene Symbols:
Ankmy2
Immunogen:
synthetic peptide directed towards the N terminal region of human ANKMY2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: ANKMY2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ankmy2
Gene Alias: AI035571; ANKMY2; ankyrin repeat and MYND domain containing 2; ankyrin repeat and MYND domain-containing protein 2; EGK_13887; Gna14; guanine nucleotide binding protein, alpha 14; LOW QUALITY PROTEIN: ankyrin repeat and MYND domain-containing protein 2; ZMYND20
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57037
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.: Q8IV38
Gene Symbols: Ankmy2
Immunogen: synthetic peptide directed towards the N terminal region of human ANKMY2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ANKMY2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ankmy2
Gene Alias:
AI035571; ANKMY2; ankyrin repeat and MYND domain containing 2; ankyrin repeat and MYND domain-containing protein 2; EGK_13887; Gna14; guanine nucleotide binding protein, alpha 14; LOW QUALITY PROTEIN: ankyrin repeat and MYND domain-containing protein 2; ZMYND20
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57037
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.:
Q8IV38
Gene Symbols:
Ankmy2
Immunogen:
synthetic peptide directed towards the N terminal region of human ANKMY2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG