PIPA575258
HPK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA575258-Each-of-1 | In Stock | ₹ 44,277.30 |
PIPA575258 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,277.30
GST (18%): ₹ 7,969.914
Total Price: ₹ 52,247.214
Antigen
HPK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP4K1
Gene Alias
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11184, 26411, 292763
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P70218, Q92918
Gene Symbols
MAP4K1
Immunogen
Synthetic peptide corresponding to amino acids 365-412 of Human HPK1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
- MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family
- MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway
- MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76
- The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells
- The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation
- We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells
- HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade
- Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo
- HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant
- Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1.
Compare Similar Items
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Antigen: HPK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAP4K1
Gene Alias: EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11184, 26411, 292763
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: P70218, Q92918
Gene Symbols: MAP4K1
Immunogen: Synthetic peptide corresponding to amino acids 365-412 of Human HPK1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
HPK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAP4K1
Gene Alias:
EC 2.7.11.1; Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; HPK1; MAP4K1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11184, 26411, 292763
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
P70218, Q92918
Gene Symbols:
MAP4K1
Immunogen:
Synthetic peptide corresponding to amino acids 365-412 of Human HPK1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: FOXB1/FOXB2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FOXB2
Gene Alias: bA159H20.4; C43; Fkh4; Fkh5; forkhead box B1; forkhead box B1a; forkhead box B1b; forkhead box B2; forkhead box protein B1; Forkhead box protein B2; forkhead homolog 4; Foxb1; Foxb1a; Foxb1b; FOXB2; Hfh-e5.1; HFKH-5; mesoderm/mesenchyme forkhead 3; Mf3; Transcription factor FKH-4; transcription factor FKH-5; Twh
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14240, 27023, 367106, 442425, 64290, 691398
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q5VYV0, Q64732, Q64733, Q99853
Gene Symbols: FOXB1, FOXB2
Immunogen: Synthetic peptide corresponding to amino acids 40-87 of Human FoxB1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
FOXB1/FOXB2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FOXB2
Gene Alias:
bA159H20.4; C43; Fkh4; Fkh5; forkhead box B1; forkhead box B1a; forkhead box B1b; forkhead box B2; forkhead box protein B1; Forkhead box protein B2; forkhead homolog 4; Foxb1; Foxb1a; Foxb1b; FOXB2; Hfh-e5.1; HFKH-5; mesoderm/mesenchyme forkhead 3; Mf3; Transcription factor FKH-4; transcription factor FKH-5; Twh
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14240, 27023, 367106, 442425, 64290, 691398
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q5VYV0, Q64732, Q64733, Q99853
Gene Symbols:
FOXB1, FOXB2
Immunogen:
Synthetic peptide corresponding to amino acids 40-87 of Human FoxB1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: ELF5
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ELF5
Gene Alias: E74 like ETS transcription factor 5; E74-like factor 5; E74-like factor 5 (ets domain transcription factor); E74-like factor 5 ESE-2a; Elf5; elf-5; Epithelium specific Ets-2; epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE2; ESE-2; ESE-5; ESE-5.; ets transcription factor; ETS-related transcription factor Elf-5
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13711, 2001, 366142
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8VDK3, Q9UKW6
Gene Symbols: ELF5
Immunogen: Synthetic peptide corresponding to amino acids 182-230 of Human Elf-5.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ELF5
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ELF5
Gene Alias:
E74 like ETS transcription factor 5; E74-like factor 5; E74-like factor 5 (ets domain transcription factor); E74-like factor 5 ESE-2a; Elf5; elf-5; Epithelium specific Ets-2; epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE2; ESE-2; ESE-5; ESE-5.; ets transcription factor; ETS-related transcription factor Elf-5
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13711, 2001, 366142
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8VDK3, Q9UKW6
Gene Symbols:
ELF5
Immunogen:
Synthetic peptide corresponding to amino acids 182-230 of Human Elf-5.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: TBX22
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TBX22
Gene Alias: ABERS; CLPA; CPX; D230020M15Rik; dJ795G23.1; T-box 22; T-box protein 22; T-box transcription factor TBX22; TBOX22; Tbx 22; TBX22; TBXX
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 245572, 302369, 50945
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8K402, Q9Y458
Gene Symbols: TBX22
Immunogen: Synthetic peptide corresponding to the N-terminual of Human TBX22.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
TBX22
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TBX22
Gene Alias:
ABERS; CLPA; CPX; D230020M15Rik; dJ795G23.1; T-box 22; T-box protein 22; T-box transcription factor TBX22; TBOX22; Tbx 22; TBX22; TBXX
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
245572, 302369, 50945
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8K402, Q9Y458
Gene Symbols:
TBX22
Immunogen:
Synthetic peptide corresponding to the N-terminual of Human TBX22.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG