PIPA578183
Phospho-MST1/MST2 (Thr183, Thr180) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA578183-Each-of-1 | In Stock | ₹ 47,357.46 |
PIPA578183 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,357.46
GST (18%): ₹ 8,524.343
Total Price: ₹ 55,881.803
Antigen
Phospho-MST1/MST2 (Thr183, Thr180)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Stk3
Gene Alias
0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6788, 6789
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1.54 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q13043, Q13188
Gene Symbols
Stk3, STK4
Immunogen
Carrier-protein conjugated synthetic peptide corresponding to residues around human MST1 (phospho Thr183)/MST2 (phospho Thr180).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: HeLa (1 μM Staurosporine treatment for 3 hr) Predicted Reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Chicken (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- STK3 and STK4 are stress-activated, pro-apoptotic kinases which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- They are key components of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
- Phosphorylates NKX2-1
- Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250
- In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation
- Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'
- Phosphorylates MOBKL1A and RASSF2
- Phosphorylates MOBKL1B on 'Thr-74'
- Acts cooperatively with MOBKL1B to activate STK38.
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Antigen: Phospho-MST1/MST2 (Thr183, Thr180)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Stk3
Gene Alias: 0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6788, 6789
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 1.54 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: Q13043, Q13188
Gene Symbols: Stk3, STK4
Immunogen: Carrier-protein conjugated synthetic peptide corresponding to residues around human MST1 (phospho Thr183)/MST2 (phospho Thr180).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MST1/MST2 (Thr183, Thr180)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Stk3
Gene Alias:
0610042I06Rik; AI447339; AU020804; Kas-2; KB-1458E12.1; kinase responsive to stress 2; KRS1; KRS2; mammalian STE20-like protein kinase 1; Mammalian STE20-like protein kinase 2; mammalian sterile 20-like 1; mess1; MST; MST1; MST-1; MST1/C; MST1/C STK4; MST1/N; MST2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine kinase 4; serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-1; serine/threonine-protein kinase Krs-2; Ste20; STE20-like kinase MST1; STE20-like kinase MST2; sterile 20-like kinase 1; STK3; Stk4; Yeast Sps1/Ste20-related kinase 3; YSK3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6788, 6789
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
1.54 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
Q13043, Q13188
Gene Symbols:
Stk3, STK4
Immunogen:
Carrier-protein conjugated synthetic peptide corresponding to residues around human MST1 (phospho Thr183)/MST2 (phospho Thr180).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: LKB1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STK11
Gene Alias: AA408040; CAMK group; CAMKL family; hLKB1; liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB1; LKB-1; LKB1(S); Par-4; PJS; polarization-related protein LKB1; R75140; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11; STK11
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20869, 6794
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.54 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: Q15831, Q9WTK7
Gene Symbols: STK11
Immunogen: Recombinant protein encompassing a sequence within the center region of human LKB1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
LKB1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STK11
Gene Alias:
AA408040; CAMK group; CAMKL family; hLKB1; liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB1; LKB-1; LKB1(S); Par-4; PJS; polarization-related protein LKB1; R75140; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11; STK11
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20869, 6794
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.54 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
Q15831, Q9WTK7
Gene Symbols:
STK11
Immunogen:
Recombinant protein encompassing a sequence within the center region of human LKB1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: TAF12
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TAF12
Gene Alias: 20kDa; 2810422D08Rik; AW557038; hypothetical protein LOC614227; TAF12; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kD; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF15; TAF2J; TAFII20; TAFII-20; TAFII20/TAFII15; TAFII-20/TAFII-15; TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD; TATA box binding protein associated factor 12; TATA-box binding protein associated factor 12; TATA-box binding protein associated factor 12; transcription initiation factor TFIID subunit 12; transcription initiation factor TFIID 20 kDa subunits; Transcription initiation factor TFIID 20/15 kDa subunits; transcription initiation factor TFIID subunit 12
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6883
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: Q16514
Gene Symbols: TAF12
Immunogen: Recombinant protein encompassing a sequence within the center region of human TAF12. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TAF12
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TAF12
Gene Alias:
20kDa; 2810422D08Rik; AW557038; hypothetical protein LOC614227; TAF12; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kD; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF15; TAF2J; TAFII20; TAFII-20; TAFII20/TAFII15; TAFII-20/TAFII-15; TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD; TATA box binding protein associated factor 12; TATA-box binding protein associated factor 12; TATA-box binding protein associated factor 12; transcription initiation factor TFIID subunit 12; transcription initiation factor TFIID 20 kDa subunits; Transcription initiation factor TFIID 20/15 kDa subunits; transcription initiation factor TFIID subunit 12
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6883
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
Q16514
Gene Symbols:
TAF12
Immunogen:
Recombinant protein encompassing a sequence within the center region of human TAF12. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TBCA
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TBCA
Gene Alias: CFA; chaperonin cofactor A; co-chaperonin associated with a- & b-tubulin; cofactor A; Tbca; Tbca13; TCP1-chaperonin cofactor A; tubulin cofactor a; tubulin folding cofactor A; tubulin-folding cofactor A; Tubulin-specific chaperone A
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6902
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 0.1 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: O75347
Gene Symbols: TBCA
Immunogen: Recombinant protein encompassing a sequence within the center region of human TBCA. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TBCA
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TBCA
Gene Alias:
CFA; chaperonin cofactor A; co-chaperonin associated with a- & b-tubulin; cofactor A; Tbca; Tbca13; TCP1-chaperonin cofactor A; tubulin cofactor a; tubulin folding cofactor A; tubulin-folding cofactor A; Tubulin-specific chaperone A
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6902
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
0.1 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
O75347
Gene Symbols:
TBCA
Immunogen:
Recombinant protein encompassing a sequence within the center region of human TBCA. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG