PIPA578272
MBD4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA578272-Each-of-1 | In Stock | ₹ 47,015.22 |
PIPA578272 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,015.22
GST (18%): ₹ 8,462.74
Total Price: ₹ 55,477.96
Antigen
MBD4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MBD4
Gene Alias
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8930
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
O95243
Gene Symbols
MBD4
Immunogen
Recombinant protein encompassing a sequence within the center region of human MBD4. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Description
- Positive Control: 3xFlag-human MBD4-transfected 293T Predicted Reactivity: Chimpanzee (97%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression
- The methylation pattern involves the enzymatic processes of methylation and demethylation
- The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD)
- The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol
- MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA
- MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal
- Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro
- MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity
- MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases
- In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Compare Similar Items
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Antigen: MBD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MBD4
Gene Alias: 3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8930
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: O95243
Gene Symbols: MBD4
Immunogen: Recombinant protein encompassing a sequence within the center region of human MBD4. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MBD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MBD4
Gene Alias:
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8930
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
O95243
Gene Symbols:
MBD4
Immunogen:
Recombinant protein encompassing a sequence within the center region of human MBD4. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: WAVE1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: WASF1
Gene Alias: AI195380; AI838537; homology of dictyostelium scar 1; KIAA0269; Protein WAVE-1; Scar; SCAR1; Verprolin homology domain-containing protein 1; WAS protein family; WAS protein family member 1; WAS protein family, member 1; WASF1; WASP family 1; WASP family protein member 1; WAVE; WAVE1; WAVE-1; Wiskott-Aldrich syndrome protein family member 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 294568, 83767, 8936
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.73 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: Q5BJU7, Q8R5H6, Q92558
Gene Symbols: WASF1
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse WAVE1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
WAVE1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
WASF1
Gene Alias:
AI195380; AI838537; homology of dictyostelium scar 1; KIAA0269; Protein WAVE-1; Scar; SCAR1; Verprolin homology domain-containing protein 1; WAS protein family; WAS protein family member 1; WAS protein family, member 1; WASF1; WASP family 1; WASP family protein member 1; WAVE; WAVE1; WAVE-1; Wiskott-Aldrich syndrome protein family member 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
294568, 83767, 8936
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.73 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
Q5BJU7, Q8R5H6, Q92558
Gene Symbols:
WASF1
Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse WAVE1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MTA1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MTA1
Gene Alias: metastasis associated 1; metastasis associated gene 1 protein; metastasis-associated protein MTA1; MTA1; Zg29
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 116870, 64520, 9112
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q13330, Q62599, Q8K4B0
Gene Symbols: MTA1
Immunogen: Recombinant protein encompassing a sequence within the center region of human MTA1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MTA1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MTA1
Gene Alias:
metastasis associated 1; metastasis associated gene 1 protein; metastasis-associated protein MTA1; MTA1; Zg29
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
116870, 64520, 9112
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q13330, Q62599, Q8K4B0
Gene Symbols:
MTA1
Immunogen:
Recombinant protein encompassing a sequence within the center region of human MTA1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: LATS1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LATS1
Gene Alias: AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9113
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 0.67 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: O95835
Gene Symbols: LATS1
Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human LATS1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
LATS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LATS1
Gene Alias:
AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9113
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
0.67 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
O95835
Gene Symbols:
LATS1
Immunogen:
Recombinant protein encompassing a sequence within the N-terminus region of human LATS1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG