PIPA578642

RNF168 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA578642-Each-of-1 In Stock ₹ 47,015.22

PIPA578642 - Each of 1

₹ 47,015.22

In Stock

Quantity

1

Base Price: ₹ 47,015.22

GST (18%): ₹ 8,462.74

Total Price: ₹ 55,477.96

Antigen

RNF168

Classification

Polyclonal

Conjugate

Unconjugated

Gene

RNF168

Gene Alias

3110001H15Rik; E3 ubiquitin-protein ligase RNF168; FLJ35794; hRNF168; RING finger protein 168; ring finger protein 168, E3 ubiquitin protein ligase; ring fnger protein 168; RING-type E3 ubiquitin transferase RNF168; RNF168

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

165918

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.

Q8IYW5

Gene Symbols

RNF168

Immunogen

Recombinant protein encompassing a sequence within the center region of human RNF168. The exact sequence is proprietary.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Related Products

Img

Thermo Scientific

PIPA578615

--

Img

Thermo Scientific

PIPA578628

--

Img

Thermo Scientific

PIPA578630

--

Img

Thermo Scientific

PIPA578632

--

Img

Thermo Scientific

PIPA578610

--

Img

Thermo Scientific

PIPA578678

--

Img

Thermo Scientific

PIPA578677

--

Img

Thermo Scientific

PIPA578611

--

Description

  • Positive Control: human RNF168-transfected 293T, MDA-MB-231, MDA-MB-231 nuclear Predicted Reactivity: Mouse (80%), Rat (82%), Chimpanzee (99%), Bovine (86%) Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo
  • RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains
  • Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner
  • This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade
  • Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance
  • At least three isoforms of RNF168 are known to exist.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA578642

--


Antigen:
RNF168

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
RNF168

Gene Alias:
3110001H15Rik; E3 ubiquitin-protein ligase RNF168; FLJ35794; hRNF168; RING finger protein 168; ring finger protein 168, E3 ubiquitin protein ligase; ring fnger protein 168; RING-type E3 ubiquitin transferase RNF168; RNF168

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
165918

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.:
Q8IYW5

Gene Symbols:
RNF168

Immunogen:
Recombinant protein encompassing a sequence within the center region of human RNF168. The exact sequence is proprietary.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA578646

--


Antigen:
ASXL1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Asxl1

Gene Alias:
additional sex combs like 1; additional sex combs like 1, transcriptional regulator; additional sex combs like transcriptional regulator 1; additional sex combs-like protein 1; Asxl1; BOPS; KIAA0978; MDS; MGC117280; MGC71111; mKIAA0978; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1; RGD1561878

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
171023, 228790

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 20% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
P59598, Q8IXJ9

Gene Symbols:
Asxl1

Immunogen:
Recombinant protein encompassing a sequence within the N-terminus region of human ASXL1. The exact sequence is proprietary.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA578647

--


Antigen:
NME7

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
NME7

Gene Alias:
CFAP67; cilia and flagella associated protein 67; D530024H21Rik; MN23H7; NDK 7; NDK7; NDP kinase 7; nm23-H7; Nm23-M7; Nm23-r7; NME/NM23 family member 7; Nme7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 7; nucleoside diphosphate kinase 7-like protein; nucleoside-diphosphate kinase; nucleoside-diphosphate kinase 7; nucleoside-diphosphate kinase 7 isoform a

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
171567, 29922

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1.08 mg/mL

Formulation:
0.1M tris glycine with 0.1M glycine, 20% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
Q9QXL8, Q9Y5B8

Gene Symbols:
NME7

Immunogen:
Mouse CD3

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA578648

--


Antigen:
NLGN1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Nlgn1

Gene Alias:
6330415N05Rik; BB179718; Kiaa1070; MGC45115; mKIAA1070; neuroligin 1; neuroligin I; Neuroligin-1; NL1; NLG 1; Nlg1; NLGN1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
116647, 192167

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Concentration:
0.39 mg/mL

Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7

Gene Accession No.:
Q62765, Q99K10

Gene Symbols:
Nlgn1

Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of mouse Neuroligin 1. The exact sequence is proprietary.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Isotype:
IgG