FGF19 Polyclonal Antibody, Invitrogen™

Description

• Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
• FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene
• The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family
• The FGF19 gene is mapped to 11q13.3
• The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family
• Expression of this gene was detected only in fetal but not adult brain tissue
• Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development
• FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis
• The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity
• The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions
• Together they are often referred to as FGF15/19.