PIPA585094
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA585094-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA585094 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17246, 4193
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1.11 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Immunogen
Recombinant protein encompassing a sequence within the center region of human MDM2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Description
- Keep as concentrated solution
- Predicted reactivity: Rat (81%), Dog (91%), Cat (95%), Pig (93%), Rhesus Monkey (98%), Bovine (95%)
- Positive Control: Jurkat, Raji, NCI-H929, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, HepG2, HepG2 (starvation and 1 uM Staurosporine treatment for 24 hr), MDM2-transfected 293T
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
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Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1.11 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: Recombinant protein encompassing a sequence within the center region of human MDM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1.11 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
Recombinant protein encompassing a sequence within the center region of human MDM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: WT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: WT1
Gene Alias: AWT1, D630046I19Rik, EWS-WT1, GUD, NPHS4, WAGR, Wilms tumor 1, Wilms tumor 1 homolog, Wilms tumor protein, Wilms tumor protein homolog, Wilms tumor protein isoform Ex4a(+), WIT1, WIT-1, WIT-2, WT, Wt1, Wt-1, WT1 antisense RNA, WT1AS, WT1-AS, WT1-AS1, WT33
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22431, 24883, 7490
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1.09 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.: P19544, P22561, P49952
Gene Symbols: WT1
Immunogen: Recombinant protein encompassing a sequence within the center region of human Wilms Tumor 1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
WT1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
WT1
Gene Alias:
AWT1, D630046I19Rik, EWS-WT1, GUD, NPHS4, WAGR, Wilms tumor 1, Wilms tumor 1 homolog, Wilms tumor protein, Wilms tumor protein homolog, Wilms tumor protein isoform Ex4a(+), WIT1, WIT-1, WIT-2, WT, Wt1, Wt-1, WT1 antisense RNA, WT1AS, WT1-AS, WT1-AS1, WT33
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22431, 24883, 7490
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1.09 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.:
P19544, P22561, P49952
Gene Symbols:
WT1
Immunogen:
Recombinant protein encompassing a sequence within the center region of human Wilms Tumor 1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunofluorescence
Concentration: 0.62 mg/mL
Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal, pH 7
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MDM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunofluorescence
Concentration:
0.62 mg/mL
Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal, pH 7
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MDM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: MMP3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MMP3
Gene Alias: CHDS6; EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metallopeptidase 3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 precursor; matrix metalloproteinase-3; metalloproteinase 3 receptor; MMP; MMP10; MMP3; MMP-3; MMP-3 protein; MMPs; progelatinase; proteoglycanase; SL-1; SLN1; SLN-1; STMY; STMY1; Str1; STR-1; stromelysin; stromelysin 1; Stromelysin1; stromelysin-1; Transin1; Transin-1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4314
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 0.73 mg/mL
Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: P08254
Gene Symbols: MMP3
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human MMP3.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MMP3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MMP3
Gene Alias:
CHDS6; EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metallopeptidase 3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 precursor; matrix metalloproteinase-3; metalloproteinase 3 receptor; MMP; MMP10; MMP3; MMP-3; MMP-3 protein; MMPs; progelatinase; proteoglycanase; SL-1; SLN1; SLN-1; STMY; STMY1; Str1; STR-1; stromelysin; stromelysin 1; Stromelysin1; stromelysin-1; Transin1; Transin-1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4314
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
0.73 mg/mL
Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
P08254
Gene Symbols:
MMP3
Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human MMP3.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG