PIPA585186
tPA Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA585186-Each-of-1 | In Stock | ₹ 44,191.74 |
PIPA585186 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,191.74
GST (18%): ₹ 7,954.513
Total Price: ₹ 52,146.253
Antigen
tPA
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PLAT
Gene Alias
3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18791, 25692, 5327
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.15 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P00750, P11214, P19637
Gene Symbols
PLAT
Immunogen
Recombinant protein encompassing a sequence within the center region of human tPA.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Keep as concentrated solution
- Predicted reactivity: Mouse (80%), Rat (82%), Pig (83%), Bovine (82%)
- Positive Control: 293T, Neuro2A, PC-12, human plasma
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
- By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
- It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
- TPA binds to fibrin with high affinity
- This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
- Similarly, binding to heparin increases the activation of plasminogen
- Binding to laminin and fibronectin has also been demonstrated
- TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
- These proteins are involved in TPA clearance
- TPA binds to annexin II and to cytokeratin 8
- As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
- In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.
Compare Similar Items
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Antigen: tPA
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PLAT
Gene Alias: 3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18791, 25692, 5327
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.15 mg/mL
Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: P00750, P11214, P19637
Gene Symbols: PLAT
Immunogen: Recombinant protein encompassing a sequence within the center region of human tPA.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
tPA
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PLAT
Gene Alias:
3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18791, 25692, 5327
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.15 mg/mL
Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
P00750, P11214, P19637
Gene Symbols:
PLAT
Immunogen:
Recombinant protein encompassing a sequence within the center region of human tPA.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Desmin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DES
Gene Alias: CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13346, 1674, 395906, 64362
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.06 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.: P02542, P17661, P31001, P48675
Gene Symbols: DES
Immunogen: Recombinant protein encompassing a sequence within the center region of human Desmin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Chicken, Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Desmin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DES
Gene Alias:
CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13346, 1674, 395906, 64362
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.06 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.:
P02542, P17661, P31001, P48675
Gene Symbols:
DES
Immunogen:
Recombinant protein encompassing a sequence within the center region of human Desmin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Chicken, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: HIF-2 alpha
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EPAS1
Gene Alias: basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain protein 1b, endothelial PAS domain-containing protein 1, endothelial PAS domain-containing protein 1b, EPAS, Epas1, EPAS-1, epas1b, Hif like protein, HIF1 alpha-like factor, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF1alpha-like factor, HIF2 alpha, HIF-2 alpha, HIF2A, hif-2a, hif-2ab, HIF-2alpha, HIF-2-alpha, HIF2-alpha, HIF-related factor, HLF, HLF (HIF1alpha-like factor), HRF, hypoxia inducible factor 2 alpha, hypoxia inducible factor 2, alpha subunit, hypoxia inducible factor 2a, hypoxia inducible transcription factor 2alpha, hypoxia-inducible factor 2 alpha, hypoxia-inducible factor 2-alpha, Member of PAS protein 2, mHLF, MOP2, PAS domain-containing protein 2, PASD2, wu:fq36f01
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2034, 555192
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: ChIP Assay, Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.: Q99814
Gene Symbols: EPAS1, epas1b
Immunogen: Recombinant protein encompassing a sequence within the center region of human HIF2 alpha.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Zebrafish
Product Type: Antibody
Isotype: IgG
Antigen:
HIF-2 alpha
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EPAS1
Gene Alias:
basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain protein 1b, endothelial PAS domain-containing protein 1, endothelial PAS domain-containing protein 1b, EPAS, Epas1, EPAS-1, epas1b, Hif like protein, HIF1 alpha-like factor, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF1alpha-like factor, HIF2 alpha, HIF-2 alpha, HIF2A, hif-2a, hif-2ab, HIF-2alpha, HIF-2-alpha, HIF2-alpha, HIF-related factor, HLF, HLF (HIF1alpha-like factor), HRF, hypoxia inducible factor 2 alpha, hypoxia inducible factor 2, alpha subunit, hypoxia inducible factor 2a, hypoxia inducible transcription factor 2alpha, hypoxia-inducible factor 2 alpha, hypoxia-inducible factor 2-alpha, Member of PAS protein 2, mHLF, MOP2, PAS domain-containing protein 2, PASD2, wu:fq36f01
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2034, 555192
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
ChIP Assay, Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300, pH 7
Gene Accession No.:
Q99814
Gene Symbols:
EPAS1, epas1b
Immunogen:
Recombinant protein encompassing a sequence within the center region of human HIF2 alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Zebrafish
Product Type:
Antibody
Isotype:
IgG
Antigen: Haptoglobin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HP
Gene Alias: alpha polypeptide; Ba1-647; beta polypeptide; binding peptide; Binding peptide (BP); BP; haptoglobin; haptoglobin alpha 1S; Haptoglobin alpha chain; Haptoglobin alpha chain / alpha(1S) beta; haptoglobin alpha(1S)-beta; Haptoglobin alpha(2FS) beta; haptoglobin alpha(2FS)-beta; Haptoglobin beta chain; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; haptoglobin; haptoglobin-like; haptoglobin-like; haptoglobin-related protein; Hp; HP-1; HP2 ALPHA2; HP2ALPHA2; HP2-ALPHA-2; HPA1S; HPR; HPT; Liver regeneration-related protein LRRG173; LOC100067869; LOC479668; MGC111141; MGC133752; preHP2; zonulin
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3240
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.59 mg/mL
Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: P00738
Gene Symbols: HP
Immunogen: Recombinant protein encompassing a sequence within the center region of human Haptoglobin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Haptoglobin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HP
Gene Alias:
alpha polypeptide; Ba1-647; beta polypeptide; binding peptide; Binding peptide (BP); BP; haptoglobin; haptoglobin alpha 1S; Haptoglobin alpha chain; Haptoglobin alpha chain / alpha(1S) beta; haptoglobin alpha(1S)-beta; Haptoglobin alpha(2FS) beta; haptoglobin alpha(2FS)-beta; Haptoglobin beta chain; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; haptoglobin; haptoglobin-like; haptoglobin-like; haptoglobin-related protein; Hp; HP-1; HP2 ALPHA2; HP2ALPHA2; HP2-ALPHA-2; HPA1S; HPR; HPT; Liver regeneration-related protein LRRG173; LOC100067869; LOC479668; MGC111141; MGC133752; preHP2; zonulin
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3240
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.59 mg/mL
Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
P00738
Gene Symbols:
HP
Immunogen:
Recombinant protein encompassing a sequence within the center region of human Haptoglobin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG