PIPA587305

IL-21 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA587305-Each-of-1 In Stock ₹ 47,614.14

PIPA587305 - Each of 1

₹ 47,614.14

In Stock

Quantity

1

Base Price: ₹ 47,614.14

GST (18%): ₹ 8,570.545

Total Price: ₹ 56,184.685

Antigen

IL-21

Classification

Polyclonal

Conjugate

Unconjugated

Gene

IL21

Gene Alias

CVID11, CX2, il 21, IL21, IL-21, ILN, Interleukin, interleukin 21, Interleukin21, interleukin-21, interleukin-21 isoform, porcine interleukin-21, Za11

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

365769, 59067, 60505

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.

A3QPB9, Q9ES17, Q9HBE4

Gene Symbols

IL21

Immunogen

Recombinant full length Human IL21.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells
  • In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6
  • As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function
  • IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells
  • In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23
  • While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3
  • IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules
  • In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA587305

--


Antigen:
IL-21

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
IL21

Gene Alias:
CVID11, CX2, il 21, IL21, IL-21, ILN, Interleukin, interleukin 21, Interleukin21, interleukin-21, interleukin-21 isoform, porcine interleukin-21, Za11

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
365769, 59067, 60505

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
A3QPB9, Q9ES17, Q9HBE4

Gene Symbols:
IL21

Immunogen:
Recombinant full length Human IL21.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA587307

--


Antigen:
GOLPH2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
GOLM1

Gene Alias:
2310001L02Rik, AW125446, bA379P1.3, C9orf155, D030064E01Rik, epididymis luminal protein 46, FLJ22634, FLJ23608, Golgi membrane protein 1, Golgi membrane protein GP73, golgi phosphoprotein 2, golgi protein, 73-kD, GOLM1, Golph2, GOLPH2Ê, GP73, HEL46, PSEC0242, PSEC0257, RP11-379P1.3, UNQ686/PRO1326

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
105348, 51280, 680692

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
Q8NBJ4, Q91XA2

Gene Symbols:
GOLM1

Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 111-270 of human GOLM1 (NP_057632.2).

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA587308

--


Antigen:
HMG20A

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
HMG20A

Gene Alias:
1200004E06Rik, 5730490E10Rik, FLJ10739, high mobility group 20A, high mobility group protein 20A, HMG box domain containing 1, HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1, HMG20A, HMGX1, HMGXB1, Ibraf, Inhibitor of BRAF35, RGD1564760

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
10363, 315689, 66867

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
Q9DC33, Q9NP66

Gene Symbols:
HMG20A

Immunogen:
Recombinant full length Human HMG20A.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA587309

--


Antigen:
SMYD3

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SMYD3

Gene Alias:
2410008A19Rik, bA74P14.1, bA74P14.1 (novel protein), histone-lysine N-methyltransferase SMYD3, KMT3E, SET and MYND domain containing 3, SET and MYND domain-containing protein 3, Smyd3, Zinc finger MYND domain-containing protein 1, zinc finger protein, subfamily 3A (MYND domain containing), 1, zinc finger, MYND domain containing 1, ZMYND1, ZNFN3A1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
64754, 69726

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.:
Q9CWR2, Q9H7B4

Gene Symbols:
SMYD3

Immunogen:
Recombinant full length Human SMYD3.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG