PIPA588098
p53 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588098-Each-of-1 | In Stock | ₹ 45,817.38 |
PIPA588098 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,817.38
GST (18%): ₹ 8,247.128
Total Price: ₹ 54,064.508
Antigen
p53
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Tp53
Gene Alias
Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22059, 24842, 7157
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.48 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
P02340, P04637, P10361
Gene Symbols
Tp53, Trp53
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 95-390 of mouse p53 (NP_0357702)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: PSQKTYQGNY GFHLGFLQSG TAKSVMCTYS PPLNKLFCQL AKTCPVQLWV SATPPAGSRV RAMAIYKKSQ HMTEVVRRCP HHERCSDGDG LAPPQHLIRV EGNLYPEYLE DRQTFRHSVV VPYEPPEAGS EYTTIHYKYM CNSSCMGGMN RRPILTIITL EDSSGNLLGR DSFEVRVCAC PGRDRRTEEE NFRKKEVLCP ELPPGSAKRA LPTCTSASPP QKKKPLDGEY FTLKIRGRKR FEMFRELNEA LELKDAHATE ESGDSRAHSS YLKTKKGQST SRHKKTMVKK VGPDSD; Positive Samples: A-431, MCF7, Mouse thymus; Cellular Location: Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress
- p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides
- p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest
- The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain
- There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization
- p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent
- Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors
- In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory
- p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy
- Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity
- Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
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Antigen: p53
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tp53
Gene Alias: Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22059, 24842, 7157
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.48 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P02340, P04637, P10361
Gene Symbols: Tp53, Trp53
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 95-390 of mouse p53 (NP_0357702)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
p53
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tp53
Gene Alias:
Antigen NY-CO-13, bbl, BCC7, bfy, bhy, cellular tumor antigen p53, Cys 51 Stop, EGK_08142, FLJ92943, HGNC11998, I79_002739, LFS1, Li-Fraumeni syndrome, mutant p53, mutant tumor protein 53, OTTMUSP00000006194, p44, p53, p53 cellular tumor antigen, p53 protein, p53 tumor suppressor, p53 tumor suppressor phosphoprotein, phosphoprotein p53, Tp53, tp53.L, transformation related protein 53, transformation-related protein 53, Trp248, Trp53, tumor protein 53, tumor protein p53, tumor protein p53 (Li-Fraumeni syndrome), tumor protein p53 L homeolog, tumor suppressor p53, tumor suppressor p53 phosphoprotein, tumor suppressor protein p53, tumor supressor p53, Tumour Protein p53, XELAEV_180196761mg, Xp53, Xrel3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22059, 24842, 7157
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.48 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P02340, P04637, P10361
Gene Symbols:
Tp53, Trp53
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 95-390 of mouse p53 (NP_0357702)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RAIDD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CRADD
Gene Alias: CASP2 and RIPK1 domain containing adaptor with death domain, CASP2 and RIPK1 domain-containing adaptor with death domain, caspase and RIP adapter with death domain, caspase and RIP adaptor with death domain, CRADD, death adaptor molecule RAIDD, death domain containing protein CRADD, death domain-containing protein CRADD, MGC9163, MRT34, RAIDD, RIP-associated ICH1/CED3-homologous protein with death domain, RIP-associated protein with a death domain
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8738
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.61 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P78560
Gene Symbols: CRADD
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_0037961)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
RAIDD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CRADD
Gene Alias:
CASP2 and RIPK1 domain containing adaptor with death domain, CASP2 and RIPK1 domain-containing adaptor with death domain, caspase and RIP adapter with death domain, caspase and RIP adaptor with death domain, CRADD, death adaptor molecule RAIDD, death domain containing protein CRADD, death domain-containing protein CRADD, MGC9163, MRT34, RAIDD, RIP-associated ICH1/CED3-homologous protein with death domain, RIP-associated protein with a death domain
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8738
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.61 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P78560
Gene Symbols:
CRADD
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_0037961)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SQSTM1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Sqstm1
Gene Alias: A170, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, FTDALS3, hypothetical protein 1, ORCA, OSF-6, Osi, OSIL, oxidative stress induced, oxidative stress induced like, p60, p62, p62B, PDB3, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, PKC-zeta-interacting protein, protein kinase C-zeta-interacting protein, sb:cb621, Sequestosome 1, sequestosome-1, Sqstm1, STAP, STONE14, ubiquitin-binding protein p62, Unknown (protein for MGC:127197), zgc:85784, ZIP, ZIP3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8878
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot, Immunohistochemistry, Western Blot
Concentration: 2.12 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: Q13501
Gene Symbols: Sqstm1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 341-440 of human SQSTM1/p62 (NP_0038911)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SQSTM1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Sqstm1
Gene Alias:
A170, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, FTDALS3, hypothetical protein 1, ORCA, OSF-6, Osi, OSIL, oxidative stress induced, oxidative stress induced like, p60, p62, p62B, PDB3, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, PKC-zeta-interacting protein, protein kinase C-zeta-interacting protein, sb:cb621, Sequestosome 1, sequestosome-1, Sqstm1, STAP, STONE14, ubiquitin-binding protein p62, Unknown (protein for MGC:127197), zgc:85784, ZIP, ZIP3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8878
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot, Immunohistochemistry, Western Blot
Concentration:
2.12 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
Q13501
Gene Symbols:
Sqstm1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 341-440 of human SQSTM1/p62 (NP_0038911)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cardiac Troponin T
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TNNT2
Gene Alias: alternatively spliced, cardiac muscle troponin T, cardiac TnT, cardiac troponin 2, cardiac troponin 2 adult #1 isoform, cardiac troponin 2 adult #2 isoform, cardiac troponin 2 embryonic #1 isoform, cardiac troponin 2 embryonic #2 isoform, cardiac troponin 2, exclusion exon 6 #1 isoform, cardiac troponin 2, exclusion exon 6 #2 isoform, cardiac troponin T, cardiac troponin T form I, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T isoform I, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, hypertrophic 2, CMD1D, CMH2, CMPD2, cTnT, Ctt, CTTG, LVNC6, MGC3889, RATCTTG, RCM3, TNNT2, Tnnt3, Tnt, TnTc, troponin T, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin T splicing mutant isoform 2, troponin T type 2 (cardiac), troponin T, cardiac muscle, Troponin T, cardiac muscle isoforms, Troponin T2, troponin T2, cardiac
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21956, 24837
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.01 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P50752, P50753
Gene Symbols: TNNT2
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Cardiac troponin T (Cardiac troponin T (TNNT2)) (NP_0010014311)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cardiac Troponin T
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TNNT2
Gene Alias:
alternatively spliced, cardiac muscle troponin T, cardiac TnT, cardiac troponin 2, cardiac troponin 2 adult #1 isoform, cardiac troponin 2 adult #2 isoform, cardiac troponin 2 embryonic #1 isoform, cardiac troponin 2 embryonic #2 isoform, cardiac troponin 2, exclusion exon 6 #1 isoform, cardiac troponin 2, exclusion exon 6 #2 isoform, cardiac troponin T, cardiac troponin T form I, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T isoform I, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, hypertrophic 2, CMD1D, CMH2, CMPD2, cTnT, Ctt, CTTG, LVNC6, MGC3889, RATCTTG, RCM3, TNNT2, Tnnt3, Tnt, TnTc, troponin T, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin T splicing mutant isoform 2, troponin T type 2 (cardiac), troponin T, cardiac muscle, Troponin T, cardiac muscle isoforms, Troponin T2, troponin T2, cardiac
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21956, 24837
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.01 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P50752, P50753
Gene Symbols:
TNNT2
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Cardiac troponin T (Cardiac troponin T (TNNT2)) (NP_0010014311)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat, Rat
Product Type:
Antibody
Isotype:
IgG