PIPA588893
MARCH8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588893-Each-of-1 | In Stock | ₹ 44,191.74 |
PIPA588893 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,191.74
GST (18%): ₹ 7,954.513
Total Price: ₹ 52,146.253
Antigen
MARCH8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MARCH8
Gene Alias
1300017E09Rik, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), CMIR, c-MIR, c-mir, cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, E3 ubiquitin-protein ligase MARCHF8, E3 ubiquitin-protein ligase MARCH8, March8, MARCHF8, MARCH-VIII, membrane associated ring finger 8, membrane associated ring-CH-type finger 8, membrane-associated ring finger (C3HC4) 8, membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase, membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MIR, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8, RING-type E3 ubiquitin transferase MARCHF8, RNF178, RP11-67C2.1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
220972, 312656, 71779
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.37 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q5T0T0, Q9DBD2
Gene Symbols
MARCH8
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 232-291 of human MARCH8 (NP_6594582)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: YNRVIYVQNC PETSKKNIFE KSPLTEPNFE NKHGYGICHS DTNSSCCTEP EDTGAEIIHV; Positive Samples: 22Rv1, U-87MG, Mouse testis, Rat testis, Rat liver; Cellular Location: Cytoplasmic vesicle membrane, Early endosome membrane, Lysosome membrane, Multi-pass membrane protein MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain)
- MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2
- MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail
- Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis
- MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression
- Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
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Antigen: MARCH8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MARCH8
Gene Alias: 1300017E09Rik, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), CMIR, c-MIR, c-mir, cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, E3 ubiquitin-protein ligase MARCHF8, E3 ubiquitin-protein ligase MARCH8, March8, MARCHF8, MARCH-VIII, membrane associated ring finger 8, membrane associated ring-CH-type finger 8, membrane-associated ring finger (C3HC4) 8, membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase, membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MIR, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8, RING-type E3 ubiquitin transferase MARCHF8, RNF178, RP11-67C2.1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 220972, 312656, 71779
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.37 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: Q5T0T0, Q9DBD2
Gene Symbols: MARCH8
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 232-291 of human MARCH8 (NP_6594582)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MARCH8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MARCH8
Gene Alias:
1300017E09Rik, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), CMIR, c-MIR, c-mir, cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, E3 ubiquitin-protein ligase MARCHF8, E3 ubiquitin-protein ligase MARCH8, March8, MARCHF8, MARCH-VIII, membrane associated ring finger 8, membrane associated ring-CH-type finger 8, membrane-associated ring finger (C3HC4) 8, membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase, membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MIR, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8, RING-type E3 ubiquitin transferase MARCHF8, RNF178, RP11-67C2.1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
220972, 312656, 71779
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.37 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q5T0T0, Q9DBD2
Gene Symbols:
MARCH8
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 232-291 of human MARCH8 (NP_6594582)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SEMA3A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SEMA3A
Gene Alias: COLL1, coll-1, collapsin 1, collapsin-1, HH16, Hsema-I, Hsema-III, MGC133243, sema D, sema domain, immunoglobulin domain (Ig), short basic domain, sec, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, sema III, SEMA1, SEMA3A, Semad, SEMAIII, SEMAL, Semaphorin 3a, semaphorin D, semaphorin III, semaphorin L, semaphorin-3A, Semaphorin-D, SemD
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20346, 29751
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.07 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O08665, Q63548
Gene Symbols: SEMA3A
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Semaphorin 3A (NP_0060711)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SEMA3A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SEMA3A
Gene Alias:
COLL1, coll-1, collapsin 1, collapsin-1, HH16, Hsema-I, Hsema-III, MGC133243, sema D, sema domain, immunoglobulin domain (Ig), short basic domain, sec, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, sema III, SEMA1, SEMA3A, Semad, SEMAIII, SEMAL, Semaphorin 3a, semaphorin D, semaphorin III, semaphorin L, semaphorin-3A, Semaphorin-D, SemD
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20346, 29751
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.07 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O08665, Q63548
Gene Symbols:
SEMA3A
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Semaphorin 3A (NP_0060711)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: WSB2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: WSB2
Gene Alias: AA673511, CS box-containing WD protein, SBA2, SOCS box-containing WD protein SWiP-2, Swip2, WD repeat and SOCS box containing 2, WD repeat and SOCS box containing protein 2, WD repeat and SOCS box-containing 2, WD repeat and SOCS box-containing protein 2, WD SOCS-box protein 2, WD-40-repeat-containing protein with a SOCS box 2, Wsb2, WSB-2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 288692, 59043
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.25 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O54929
Gene Symbols: WSB2
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human WSB2 (NP_0611091)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
WSB2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
WSB2
Gene Alias:
AA673511, CS box-containing WD protein, SBA2, SOCS box-containing WD protein SWiP-2, Swip2, WD repeat and SOCS box containing 2, WD repeat and SOCS box containing protein 2, WD repeat and SOCS box-containing 2, WD repeat and SOCS box-containing protein 2, WD SOCS-box protein 2, WD-40-repeat-containing protein with a SOCS box 2, Wsb2, WSB-2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
288692, 59043
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.25 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O54929
Gene Symbols:
WSB2
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human WSB2 (NP_0611091)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Ataxin 3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ATXN3
Gene Alias: 2210008M02Rik, AI463012, AI647473, AT3, ataxin 3, ataxin 3 variant an, ataxin 3 variant ao, ataxin 3 variant at, ataxin 3 variant e, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant r, ataxin 3 variant ref, ataxin 3 variant y, ataxin3, ataxin-3, ATX3, ATXN3, JOS, josephin, Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3), Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog, Machado-Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD, MJD1, olivopontocerebellar ataxia 3, Rsca3, Sca3, spin, Spinocerebellar ataxia type 3 protein
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 110616, 4287
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.15 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P54252, Q9CVD2
Gene Symbols: ATXN3
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human Ataxin-3 (ATXN3) (NP_004984.2).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Ataxin 3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ATXN3
Gene Alias:
2210008M02Rik, AI463012, AI647473, AT3, ataxin 3, ataxin 3 variant an, ataxin 3 variant ao, ataxin 3 variant at, ataxin 3 variant e, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant r, ataxin 3 variant ref, ataxin 3 variant y, ataxin3, ataxin-3, ATX3, ATXN3, JOS, josephin, Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3), Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog, Machado-Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD, MJD1, olivopontocerebellar ataxia 3, Rsca3, Sca3, spin, Spinocerebellar ataxia type 3 protein
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
110616, 4287
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.15 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P54252, Q9CVD2
Gene Symbols:
ATXN3
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human Ataxin-3 (ATXN3) (NP_004984.2).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG