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PIPA588954

ITGB1BP1 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA588954-Each-of-1 In Stock ₹ 44,705.10

PIPA588954 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

ITGB1BP1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

ITGB1BP1

Gene Alias

AI449260, AU019480, bodenin, DKFZp686K08158, Icap1, ICAP-1, ICAP1A, ICAP-1A, ICAP-1alpha, ICAP1B, ICAP-1B, integrin beta 1 binding protein 1, integrin beta-1-binding protein 1, Integrin cytoplasmic domain-associated protein 1, integrin cytoplasmic domain-associated protein 1-alpha, integrin cytoplasmic domain-associated protein 1-beta, integrin subunit beta 1 binding protein 1, ITGB1BP1

Host Species

Rabbit

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

9270

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Western Blot

Concentration

3.26 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.3

Gene Accession No.

O14713

Gene Symbols

ITGB1BP1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ITGB1BP1 (NP_0047541)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • Immunogen sequence: MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS GQSNNNSDTC AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK LPFVPPEEEF IMGVSKYGIK VSTSDQYDVL HRHALYLIIR MVCYDDGLGA GKSLLALKTT DASNEEYSLW VYQCNSLEQA QAICKVLSTA FDSVLTSEKP; Positive Samples: 22RV1; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Nucleus, cytoskeleton, lamellipodium, ruffle Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1
  • Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis
  • Stimulates cellular proliferation in a fibronectin-dependent manner
  • Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner
  • Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin
  • Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool
  • Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin
  • Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis
  • Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway
  • Promotes transcriptional activity of the MYC promoter.

Compare Similar Items

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Img

Thermo Scientific

PIPA588954

--

Antigen:
ITGB1BP1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ITGB1BP1
Gene Alias:
AI449260, AU019480, bodenin, DKFZp686K08158, Icap1, ICAP-1, ICAP1A, ICAP-1A, ICAP-1alpha, ICAP1B, ICAP-1B, integrin beta 1 binding protein 1, integrin beta-1-binding protein 1, Integrin cytoplasmic domain-associated protein 1, integrin cytoplasmic domain-associated protein 1-alpha, integrin cytoplasmic domain-associated protein 1-beta, integrin subunit beta 1 binding protein 1, ITGB1BP1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9270
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
3.26 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O14713
Gene Symbols:
ITGB1BP1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ITGB1BP1 (NP_0047541)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA588957

--

Antigen:
PTDSS1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PTDSS1
Gene Alias:
KIAA0024, LMHD, Phosphatidylserine synthase 1, PSS1, PSS-1, PSSA, ptdSer synthase 1, PTDSS1, Serine-exchange enzyme I
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9791
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
2 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P48651
Gene Symbols:
PTDSS1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PTDSS1 (NP_0555691)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA588958

--

Antigen:
GAB2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GAB2
Gene Alias:
AI463667, D130058I17Rik, GAB2, Grb2 associated binder 2, GRB2 associated binding protein 2, GRB2-associated binder 2, GRB2-associated binding protein 2, GRB2-associated-binding protein 2, GRB3-3, Growth factor receptor bound protein 2-associated protein 2, KIAA0571, p97, PH domain-containing adaptor molecule p97, pp100
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14389, 9846
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.37 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q9UQC2, Q9Z1S8
Gene Symbols:
GAB2
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_5367391)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG

Img

Thermo Scientific

PIPA588961

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Antigen:
BET1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BET1
Gene Alias:
BET1, Bet1 golgi vesicular membrane trafficking protein, BET1 homolog, Bet1p homolog, blocked early in transport 1 homolog, Golgi vesicular membrane trafficking protein p18, golgi vesicular membrane-trafficking protein p18, hBET1, rBET1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10282
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.83 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O15155
Gene Symbols:
BET1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human BET1 (NP_0058591)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG